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Human antibodies induce arthritis in mice deficient in the low-affinity inhibitory IgG receptor FcγRIIB
- Source :
- The Journal of Experimental Medicine
- Publication Year :
- 2006
- Publisher :
- Rockefeller University Press, 2006.
-
Abstract
- Rheumatoid arthritis (RA) is a complex autoimmune disease with a poorly understood pathogenesis. The disease is associated with polyclonal B cell activation and the production of autoantibodies (autoAbs), but there is a longstanding controversy as to whether such Abs contribute to, or are secondary to, the pathogenesis of RA. To address the potential pathogenicity of human RA–associated Abs, we developed a passive transfer model involving mice deficient in the low-affinity inhibitory Fc receptor, FcγRIIB. We report that plasma or serum from patients with active RA can induce inflammation and histological lesions in FcγRIIB−/− mice consistent with arthritis, and that this pathogenic activity is caused by the immunoglobulin G–rich fraction. Our results suggest that humoral autoimmunity can contribute directly to autoimmune arthritis, and that FcγRIIB−/− mice are a promising model to evaluate the arthritogenic potential of human autoAbs.
- Subjects :
- Male
Immunology
Fc receptor
Arthritis
Immunoglobulin G
Arthritis, Rheumatoid
Pathogenesis
Mice
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Immunology and Allergy
Autoantibodies
030304 developmental biology
Mice, Knockout
030203 arthritis & rheumatology
Autoimmune disease
0303 health sciences
biology
business.industry
Receptors, IgG
Brief Definitive Report
Autoantibody
medicine.disease
Arthritis, Experimental
3. Good health
Mice, Inbred C57BL
Rheumatoid arthritis
biology.protein
Brief Definitive Reports
Female
Binding Sites, Antibody
Antibody
business
Injections, Intraperitoneal
Subjects
Details
- ISSN :
- 15409538 and 00221007
- Volume :
- 203
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental Medicine
- Accession number :
- edsair.doi.dedup.....97ad6dc75dd5a023e92629100decad84