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Network pharmacology-based and clinically relevant prediction of the active ingredients and potential targets of Chinese herbs in metastatic breast cancer patients
- Source :
- Oncotarget
- Publication Year :
- 2017
- Publisher :
- Impact Journals, LLC, 2017.
-
Abstract
- // Yu Mao 1, * , Jian Hao 1, * , Zi-Qi Jin 2 , Yang-Yang Niu 3 , Xue Yang 1 , Dan Liu 1 , Rui Cao 4 , Xiong-Zhi Wu 4 1 Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China 2 Tianjin Medical University, Tianjin, 300070, China 3 Tianjin Children’s Hospital, Tianjin, 300134, China 4 Zhong-Shan-Men Inpatient Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China * These authors have contributed equally to this study and share first authorship Correspondence to: Xiong-Zhi Wu, email: wuxiongzhi@163.com Keywords: metastatic breast cancer, Chinese herbal medicine, network pharmacology, estrogen receptor, HSP90 Received: October 25, 2016 Accepted: January 22, 2017 Published: February 15, 2017 ABSTRACT Chinese Herbal Medicine (CHM) plays a significant role in breast cancer treatment. We conduct the study to ascertain the relative molecular targets of effective Chinese herbs in treating stage IV breast cancer. Survival benefit of CHM was verified by Kaplan-Meier method and Cox regression analysis. A bivariate correlation analysis was used to find and establish the effect of herbs in complex CHM formulas. A network pharmacological approach was adopted to explore the potential mechanisms of CHM. Patients in the CHM group had a median survival time of 55 months, which was longer than the 23 months of patients in the non-CHM group. Cox regression analysis indicated that CHM was an independent protective factor. Correlation analysis showed that 10 herbs were strongly correlated with favorable survival outcomes ( P
- Subjects :
- Adult
0301 basic medicine
Oncology
medicine.medical_specialty
Drug Compounding
Alternative medicine
Estrogen receptor
Breast Neoplasms
Kaplan-Meier Estimate
complex mixtures
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Biomarkers, Tumor
medicine
Humans
network pharmacology
HSP90
Medicine, Chinese Traditional
Neoplasm Metastasis
Aged
Neoplasm Staging
Proportional Hazards Models
Cancer prevention
Traditional medicine
business.industry
Proportional hazards model
Cancer
Middle Aged
Prognosis
medicine.disease
Combined Modality Therapy
Metastatic breast cancer
030104 developmental biology
Clinical research
030220 oncology & carcinogenesis
Female
metastatic breast cancer
Chinese herbal medicine
business
Drugs, Chinese Herbal
Signal Transduction
Research Paper
estrogen receptor
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....97a9a96f63534db769fc809eac6b0d51