Back to Search
Start Over
Effect of subcutaneous administration of dalteparin on lupus anticoagulant assays
- Source :
- Thrombosis research. 115(6)
- Publication Year :
- 2004
-
Abstract
- Introduction Treatment with unfractionated heparin (UH) is known to affect screening tests for lupus anticoagulant (LA). False positive test results are common because confirmatory steps lack sufficient specificity to distinguish between LA and the presence of heparin. In this study, we wanted to see if therapeutic levels of low-molecular weight heparin (LMWH) may cause false positive tests for LA or alter the LA test results in LA-positive patients. We also wanted to evaluate the need to include heparin-neutralizing agents in the reagents. Materials and methods Six healthy subjects without LA and six LA-positive patients were given 100 IU/kg dalteparin subcutaneously (s.c.). Samples for three in-house and two commercially available LA tests were taken before and 4 h after the injection. LA test results were calculated as normalized screening/confirm ratios or as recommended by the manufacturers. Results With both healthy subjects and LA patients, only small and clinically unimportant differences in mean clotting times and final test results were seen 4 h after subcutaneous dalteparin injections, at anti-FXa activities within the therapeutic range. Conclusions Our study with dalteparin suggests that LMWH therapy with plasma concentrations within the therapeutic range does not cause false positive tests for LA when normalized screening/confirm ratios are applied; nor do test results for LA-positive patients seem to be significantly altered. Heparin-neutralizing agents did not influence test performance.
- Subjects :
- Adult
Dalteparin
Male
medicine.medical_specialty
medicine.drug_class
Injections, Subcutaneous
Low molecular weight heparin
Gastroenterology
Sensitivity and Specificity
Therapeutic index
Internal medicine
medicine
Humans
False Positive Reactions
Prothrombin time
Lupus anticoagulant
Dalteparin sodium
medicine.diagnostic_test
business.industry
Heparin
Reproducibility of Results
Hematology
Middle Aged
medicine.disease
Endocrinology
Clotting time
Lupus Coagulation Inhibitor
Test performance
Female
Blood Coagulation Tests
business
medicine.drug
Subjects
Details
- ISSN :
- 00493848
- Volume :
- 115
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Thrombosis research
- Accession number :
- edsair.doi.dedup.....97a5c2b600f8d0631a1bf759e3efbf9f