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Development of Parvifloron D-loaded Smart Nanoparticles to Target Pancreatic Cancer
- Source :
- Pharmaceutics, Volume 10, Issue 4, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, Pharmaceutics, Vol 10, Iss 4, p 216 (2018)
- Publication Year :
- 2018
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2018.
-
Abstract
- Pancreatic cancer is the eighth leading cause of cancer death worldwide. For this reason, the development of more effective therapies is a major concern for the scientific community. Accordingly, plants belonging to Plectranthus genus and their isolated compounds, such as Parvifloron D, were found to have cytotoxic and antiproliferative activities. However, Parvifloron D is a very low water-soluble compound. Thus, nanotechnology can be a promising delivery system to enhance drug solubility and targeted delivery. The extraction of Parvifloron D from P. ecklonii was optimized through an acetone ultrasound-assisted method and isolated by Flash-Dry Column Chromatography. Then, its antiproliferative effect was selectivity evaluated against different tumor cell lines (IC50 of 0.15 &plusmn<br />0.05 &mu<br />M, 11.9 &plusmn<br />0.7 &mu<br />M, 21.6 &plusmn<br />0.5, 34.3 &plusmn<br />4.1 &mu<br />M, 35.1 &plusmn<br />2.2 &mu<br />M and 32.1 &plusmn<br />4.3 &mu<br />M for BxPC3, PANC-1, Ins1-E, MCF-7, HaCat and Caco-2, respectively). To obtain an optimized stable Parvifloron D pharmaceutical dosage form, albumin nanoparticles were produced through a desolvation method (yield of encapsulation of 91.2%) and characterized in terms of size (165 nm<br />PI 0.11), zeta potential (&minus<br />7.88 mV) and morphology. In conclusion, Parvifloron D can be efficiently obtained from P. ecklonii and it has shown selective cytotoxicity to pancreatic cell lines. Parvifloron D nanoencapsulation can be considered as a possible efficient alternative approach in the treatment of pancreatic cancer.
- Subjects :
- Plectranthus
Cytotoxicity
lcsh:RS1-441
Pharmaceutical Science
02 engineering and technology
Dosage form
Article
lcsh:Pharmacy and materia medica
03 medical and health sciences
0302 clinical medicine
Column chromatography
Plectranthus ecklonii
Pancreatic cancer
Zeta potential
medicine
Solubility
IC50
Chromatography
biology
Chemistry
021001 nanoscience & nanotechnology
medicine.disease
biology.organism_classification
HaCaT
030220 oncology & carcinogenesis
Parvifloron D
Nanoparticles
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....978f40132b09547b5d04fb94f4914b5d
- Full Text :
- https://doi.org/10.3390/pharmaceutics10040216