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Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration
- Source :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, RMD Open, 6(3). BMJ Publishing Group, RMD Open, Michelsen, B, Lindström, U, Codreanu, C, Ciurea, A, Zavada, J, Loft, A G, Pombo-Suarez, M, Onen, F, Kvien, T K, Rotar, Z, Santos, M J, Iannone, F, Hokkanen, A-M, Gudbjornsson, B, Askling, J, Ionescu, R, Nissen, M J, Pavelka, K, Sanchez-Piedra, C, Akar, S, Sexton, J, Tomsic, M, Santos, H, Sebastiani, M, Österlund, J, Geirsson, A J, Macfarlane, G, van der Horst-Bruinsma, I, Georgiadis, S, Brahe, C H, Ørnbjerg, L M, Hetland, M L & Østergaard, M 2020, ' Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment: routine care data from 13 registries in the EuroSpA collaboration ', RMD Open, vol. 6, no. 3 . https://doi.org/10.1136/rmdopen-2020-001280, Michelsen, B, Lindström, U, Codreanu, C, Ciurea, A, Zavada, J, Loft, A G, Pombo-Suarez, M, Onen, F, Kvien, T K, Rotar, Z, Santos, M J, Iannone, F, Hokkanen, A M, Gudbjornsson, B, Askling, J, Ionescu, R, Nissen, M J, Pavelka, K, Sanchez-Piedra, C, Akar, S, Sexton, J, Tomsic, M, Santos, H, Sebastiani, M, Österlund, J, Geirsson, A J, Macfarlane, G, van der Horst-Bruinsma, I, Georgiadis, S, Brahe, C H, Ørnbjerg, L M, Hetland, M L & Østergaard, M 2020, ' Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration ', RMD Open, vol. 6, no. 3 . https://doi.org/10.1136/rmdopen-2020-001280, Michelsen, B, Lindström, U, Codreanu, C, Ciurea, A, Zavada, J, Loft, A G, Pombo-Suarez, M, Onen, F, Kvien, T K, Rotar, Z, Santos, M J, Iannone, F, Hokkanen, A M, Gudbjornsson, B, Askling, J, Ionescu, R, Nissen, M J, Pavelka, K, Sanchez-Piedra, C, Akar, S, Sexton, J, Tomsic, M, Santos, H, Sebastiani, M, Österlund, J, Geirsson, A J, Macfarlane, G, van der Horst-Bruinsma, I, Georgiadis, S, Brahe, C H, Ørnbjerg, L M, Hetland, M L & Østergaard, M 2020, ' Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration ', RMD Open, vol. 6, no. 3, e001280 . https://doi.org/10.1136/rmdopen-2020-001280
- Publication Year :
- 2020
- Publisher :
- BMJ Publishing Group Ltd, 2020.
-
Abstract
- Publisher's version (útgefin grein)<br />OBJECTIVES: To explore 6-month and 12-month secukinumab effectiveness in patients with axial spondyloarthritis (axSpA) overall, as well as across (1) number of previous biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs), (2) time since diagnosis and (3) different European registries. METHODS: Real-life data from 13 European registries participating in the European Spondyloarthritis Research Collaboration Network were pooled. Kaplan-Meier with log-rank test, Cox regression, χ² and logistic regression analyses were performed to assess 6-month and 12-month secukinumab retention, inactive disease/low-disease-activity states (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)<br />The EuroSpA collaboration was financially supported by Novartis. Novartishad no influence on the data collection, statistical analyses, manuscript preparationor decision to submit. The national registries have received financial support froma range of pharmaceutical companies, including Novartis. These funds are given asunrestricted grants
- Subjects :
- Drug
medicine.medical_specialty
media_common.quotation_subject
education
Immunology
DMARDs (biologic)
Antibodies, Monoclonal, Humanized
Logistic regression
Severity of Illness Index
DMARDs
03 medical and health sciences
0302 clinical medicine
Rheumatology
Internal medicine
Spondylarthritis
Spondyloarthritis
medicine
Humans
Immunology and Allergy
Registries
030212 general & internal medicine
Axial spondyloarthritis
BASDAI
media_common
030203 arthritis & rheumatology
Ankylosing spondylitis
Proportional hazards model
business.industry
medicine.disease
Lyfjagjöf
3. Good health
Pharmaceutical Preparations
Outcomes research
3121 General medicine, internal medicine and other clinical medicine
Secukinumab
Iktsýki
business
Subjects
Details
- Language :
- English
- ISSN :
- 20565933
- Database :
- OpenAIRE
- Journal :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, RMD Open, 6(3). BMJ Publishing Group, RMD Open, Michelsen, B, Lindström, U, Codreanu, C, Ciurea, A, Zavada, J, Loft, A G, Pombo-Suarez, M, Onen, F, Kvien, T K, Rotar, Z, Santos, M J, Iannone, F, Hokkanen, A-M, Gudbjornsson, B, Askling, J, Ionescu, R, Nissen, M J, Pavelka, K, Sanchez-Piedra, C, Akar, S, Sexton, J, Tomsic, M, Santos, H, Sebastiani, M, Österlund, J, Geirsson, A J, Macfarlane, G, van der Horst-Bruinsma, I, Georgiadis, S, Brahe, C H, Ørnbjerg, L M, Hetland, M L & Østergaard, M 2020, ' Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment: routine care data from 13 registries in the EuroSpA collaboration ', RMD Open, vol. 6, no. 3 . https://doi.org/10.1136/rmdopen-2020-001280, Michelsen, B, Lindström, U, Codreanu, C, Ciurea, A, Zavada, J, Loft, A G, Pombo-Suarez, M, Onen, F, Kvien, T K, Rotar, Z, Santos, M J, Iannone, F, Hokkanen, A M, Gudbjornsson, B, Askling, J, Ionescu, R, Nissen, M J, Pavelka, K, Sanchez-Piedra, C, Akar, S, Sexton, J, Tomsic, M, Santos, H, Sebastiani, M, Österlund, J, Geirsson, A J, Macfarlane, G, van der Horst-Bruinsma, I, Georgiadis, S, Brahe, C H, Ørnbjerg, L M, Hetland, M L & Østergaard, M 2020, ' Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration ', RMD Open, vol. 6, no. 3 . https://doi.org/10.1136/rmdopen-2020-001280, Michelsen, B, Lindström, U, Codreanu, C, Ciurea, A, Zavada, J, Loft, A G, Pombo-Suarez, M, Onen, F, Kvien, T K, Rotar, Z, Santos, M J, Iannone, F, Hokkanen, A M, Gudbjornsson, B, Askling, J, Ionescu, R, Nissen, M J, Pavelka, K, Sanchez-Piedra, C, Akar, S, Sexton, J, Tomsic, M, Santos, H, Sebastiani, M, Österlund, J, Geirsson, A J, Macfarlane, G, van der Horst-Bruinsma, I, Georgiadis, S, Brahe, C H, Ørnbjerg, L M, Hetland, M L & Østergaard, M 2020, ' Drug retention, inactive disease and response rates in 1860 patients with axial spondyloarthritis initiating secukinumab treatment : routine care data from 13 registries in the EuroSpA collaboration ', RMD Open, vol. 6, no. 3, e001280 . https://doi.org/10.1136/rmdopen-2020-001280
- Accession number :
- edsair.doi.dedup.....978ccb19c28c7f1cd3383e9237ca59cb