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Consuming Sucrose- or HFCS-sweetened Beverages Increases Hepatic Lipid and Decreases Insulin Sensitivity in Adults
- Source :
- The Journal of Clinical Endocrinology and Metabolism
- Publication Year :
- 2021
-
Abstract
- Context Studies in rodents and humans suggest that high-fructose corn syrup (HFCS)–sweetened diets promote greater metabolic dysfunction than sucrose-sweetened diets. Objective To compare the effects of consuming sucrose-sweetened beverage (SB), HFCS-SB, or a control beverage sweetened with aspartame on metabolic outcomes in humans. Methods A parallel, double-blinded, NIH-funded study. Experimental procedures were conducted during 3.5 days of inpatient residence with controlled feeding at a research clinic before (baseline) and after a 12-day outpatient intervention period. Seventy-five adults (18-40 years) were assigned to beverage groups matched for sex, body mass index (18-35 kg/m2), and fasting triglyceride, lipoprotein and insulin concentrations. The intervention was 3 servings/day of sucrose- or HFCS-SB providing 25% of energy requirement or aspartame-SB, consumed for 16 days. Main outcome measures were %hepatic lipid, Matsuda insulin sensitivity index (ISI), and Predicted M ISI. Results Sucrose-SB increased %hepatic lipid (absolute change: 0.6 ± 0.2%) compared with aspartame-SB (-0.2 ± 0.2%, P Conclusion Consumption of both sucrose- and HFCS-SB induced detrimental changes in hepatic lipid, insulin sensitivity, and circulating lipids, lipoproteins and uric acid in 2 weeks.
- Subjects :
- Adult
Male
medicine.medical_specialty
Sucrose
food.ingredient
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Context (language use)
Biochemistry
Body Mass Index
lipids
chemistry.chemical_compound
Endocrinology
food
Double-Blind Method
Internal medicine
medicine
Humans
insulin sensitivity
Clinical Research Articles
Sugar-Sweetened Beverages
Triglyceride
High-fructose corn syrup
business.industry
Insulin
Biochemistry (medical)
liver fat
Prognosis
Corn syrup
chemistry
Liver
high-fructose corn syrup
Sweetening Agents
Uric acid
Female
Insulin Resistance
business
Body mass index
High Fructose Corn Syrup
Biomarkers
AcademicSubjects/MED00250
Lipoprotein
Follow-Up Studies
Subjects
Details
- ISSN :
- 19457197
- Volume :
- 106
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....9783d9fb09a87400ff66f522823bf98e