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Lack of association of ovariectomy-induced obesity with overeating and the reduction of physical activities
- Source :
- Biochemistry and Biophysics Reports, Biochemistry and Biophysics Reports, Vol 20, Iss, Pp-(2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Obesity commonly occurs in postmenopausal women, increasing the risk of various diseases. Estrogen can prevent obesity by activating lipid metabolism and suppressing depressive behavior. However, the reasons for obesity in postmenopausal women are not clearly elucidated. To mimic the effect of estrogen decline in postmenopausal women, we analyzed the behavior and the lipid metabolism-related genes, PPARγ and CD36 in ovariectomized (OVX) mice. The OVX mice showed increased visceral fat mass and PPARγ and CD36 expression in the visceral fat. In contrast, they were not significantly affected in terms of physical activity and food intake. Further, subcutaneous supplementation of estrogen effectively suppressed the increase in subcutaneous and visceral fat mass in OVX mice. We conclude that obesity in postmenopausal women is unlikely to be caused by overeating and reduction in physical activity, and subcutaneous supplementation of estrogen is an effective strategy to prevent obesity in postmenopausal women.<br />Highlights • We studied the effects of estrogen deficiency/supplementation on obesity in mice. • After ovariectomy, the study animals received transdermal injections of estrogen. • Exogenous 17β-estradiol appears to mediate the effects of menopause on obesity. • Obesity in the mice was caused solely by estrogen deficiency, not overeating. • Estrogen deficiency altered the mechanics of fat deposition in the mice.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Food intake
medicine.drug_class
CD36
Biophysics
Biochemistry
lcsh:Biochemistry
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
lcsh:QD415-436
Obesity
Overeating
lcsh:QH301-705.5
Exercise
Postmenopausal women
biology
business.industry
Lipid metabolism
medicine.disease
Estrogen
030104 developmental biology
Endocrinology
lcsh:Biology (General)
030220 oncology & carcinogenesis
Ovariectomized rat
biology.protein
business
hormones, hormone substitutes, and hormone antagonists
Research Article
Subjects
Details
- ISSN :
- 24055808
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Biochemistry and Biophysics Reports
- Accession number :
- edsair.doi.dedup.....9779f7a3e603d6f4a19555f1383ee43a