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Iridium-Catalyzed Stereoselective Allylic Alkylation Reactions with Crotyl Chloride
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- The development of the first enantio-, diastereo-, and regioselective iridium-catalyzed allylic alkylation reaction of prochiral enolates to form an all-carbon quaternary stereogenic center with an aliphatic-substituted allylic electrophile is disclosed. The reaction proceeds with good to excellent selectivity with a range of substituted tetralone-derived nucleophiles furnishing products bearing a newly formed vicinal tertiary and all-carbon quaternary stereodyad. The utility of this protocol is further demonstrated via a number of synthetically diverse product transformations.
- Subjects :
- Allylic rearrangement
Alkylation
Alkenes
Iridium
010402 general chemistry
01 natural sciences
Catalysis
Article
Stereocenter
chemistry.chemical_compound
Tsuji–Trost reaction
Nucleophile
Crotyl chloride
Organic chemistry
Tetralones
Molecular Structure
Chemistry
010405 organic chemistry
Regioselectivity
Stereoisomerism
General Chemistry
General Medicine
Combinatorial chemistry
0104 chemical sciences
Allyl Compounds
Electrophile
Stereoselectivity
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....9779e1db0dca8db5d58e680c694fa760