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Cortisol, Amyloid-β, and Reserve Predicts Alzheimer's Disease Progression for Cognitively Normal Older Adults
- Source :
- Journal of Alzheimer's disease 70(2), 553-562 (2019). doi:10.3233/JAD-181030
- Publication Year :
- 2019
- Publisher :
- IOS Press, 2019.
-
Abstract
- Elevated cortisol as a measure of hypothalamic-pituitary-adrenal-axis hyperactivity has emerged as a predictor of clinical progression of Alzheimer’s disease (AD), in conjunction with amyloid-β (Aβ) abnormalities. Yet factors exist which have the propensity to delay AD symptomatic expression in the face of an AD-type biomarker-based pathological profile. This study sought to determine whether abnormal cerebrospinal fluid (CSF) Aβ and elevated cortisol levels are associated with clinical transition to mild cognitive impairment (MCI) and AD in cognitively normal (CN) individuals, and if this association is modified by reserve proxies. Data from 91 CN individuals participating in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) with available morning CSF cortisol and Aβ42 were evaluated. Reserve was modelled as a latent composite score of standardized intracranial volume and lifetime experience proxies. Cox regressions were used to test associations between baseline CSF cortisol/Aβ42, reserve score and AD progression; adjusting for age, sex, apolipoprotein E genotype, and depressive symptoms. Individuals with elevated cortisol + abnormal Aβ42 levels at baseline showed highest risk of clinical progression. After a median of 84 months follow-up, significant cortisol/Aβ/ reserve interaction for clinical progression was noted (adjusted HR = 0.15, p
- Subjects :
- 0301 basic medicine
Apolipoprotein E
Oncology
Male
Hydrocortisone
1702 Cognitive Sciences
Disease
cerebrospinal fluid [Amyloid beta-Peptides]
Cognition
0302 clinical medicine
Cerebrospinal fluid
cerebrospinal fluid [Hydrocortisone]
Cognitive Reserve
Medicine
Morning
Cognitive reserve
Aged, 80 and over
General Neuroscience
physiology [Cognition]
amyloid
General Medicine
cerebrospinal fluid [Alzheimer Disease]
Psychiatry and Mental health
Clinical Psychology
cerebrospinal fluid [Biomarkers]
Disease Progression
Biomarker (medicine)
Female
Alzheimer’s disease
Alzheimer's Disease Neuroimaging Initiative
medicine.medical_specialty
cortisol
03 medical and health sciences
Alzheimer Disease
Predictive Value of Tests
Internal medicine
Humans
ddc:610
cerebrospinal fluid [Peptide Fragments]
Pathological
Aged
Neurology & Neurosurgery
Amyloid beta-Peptides
business.industry
1103 Clinical Sciences
Alzheimer’s Disease Neuroimaging Initiative
Peptide Fragments
physiology [Cognitive Reserve]
030104 developmental biology
Geriatrics and Gerontology
1109 Neurosciences
business
diagnostic imaging [Alzheimer Disease]
Biomarkers
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease 70(2), 553-562 (2019). doi:10.3233/JAD-181030
- Accession number :
- edsair.doi.dedup.....9777d64895f6e3b1a010b91cfed313e9