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Reappraisal of antibodies against Saccharomyces cerevisiae (ASCA) as persistent biomarkers in quiescent Crohn’s disease
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- A clear correlation exists between microbiota and the dysregulation of the immune response in Inflammatory Bowel Diseases (IBD), which comprise Crohn’s disease (CD) and ulcerative colitis (UC). These unbalanced reactions also involve humoral responses, with antibodies against Saccharomyces cerevisiae. Thus, here we aimed to quantify IgA and IgG specific to S. cerevisiae (ASCA) in quiescent CD and UC, to correlate the production of these antibodies with patient’s inflammatory response and disease clinical presentation. Twenty-nine subjects (16 CD and 13 UC) and 45 healthy controls were enrolled in this study and had plasma samples tested for ASCA and cytokines (IL-2, IL-4, IL-6, IL-10, IFN-γ, TNF-α), besides clinical evaluation. IBD patients had increase IgA and IgG ASCA, especially those with colonic (L2) and fistulizing (B3) CD. Similarly, patients who dropped out the treatment had augmented ASCA, while IgG was reduced in those receiving sulfasalazine treatment. Furthermore, the quiescent CD patients had elevated IL-6 on plasma, especially in the absence of treatment, together with increased counter regulatory response of IL-10. There was a positive correlation between IgA and IgG on CD but not UC, as well as between IgA and TNF in total IBD patients. In addition, the levels of IgG x TNF, IgA x IL-10 and IgG x IL-10 were also correlated in CD, indicating that ASCA production may be influenced by the inflammatory response. Finally, we concluded that ASCA could be pointed as relevant biomarker of CD presentation and residual inflammation, even in clinical remission patients.
- Subjects :
- Adult
Male
Immunology
Saccharomyces cerevisiae
Disease
digestive system
Inflammatory bowel disease
Immune system
Crohn Disease
medicine
Humans
Immunology and Allergy
Antibodies, Fungal
Aged
Crohn's disease
biology
business.industry
Inflammatory Bowel Diseases
Middle Aged
medicine.disease
biology.organism_classification
Ulcerative colitis
digestive system diseases
Immunoglobulin A
Immunoglobulin G
biology.protein
Cytokines
Female
Antibody
business
SACCHAROMYCES
Subjects
Details
- ISSN :
- 1607842X and 08916934
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Autoimmunity
- Accession number :
- edsair.doi.dedup.....9775363822ae64717a727704ec55d191