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Molecular Pathogenesis and Interventional Strategies for Alzheimer’s Disease: Promises and Pitfalls

Authors :
Kiran Kalia
Pallavi Rane
Deepaneeta Sarmah
Kunjan R. Dave
Aishika Datta
Amit Shard
Anupom Borah
Shashikala Bhute
Pallab Bhattacharya
Avirag Goswami
Source :
ACS Pharmacol Transl Sci
Publication Year :
2020
Publisher :
American Chemical Society (ACS), 2020.

Abstract

[Image: see text] Alzheimer’s disease (AD) is a debilitating disorder characterized by age-related dementia, which has no effective treatment to date. β-Amyloid depositions and hyperphosphorylated tau proteins are the main pathological hallmarks, along with oxidative stress, N-methyl-d-aspartate (NMDA) receptor-mediated excitotoxicity, and low levels of acetylcholine. Current pharmacotherapy for AD only provides symptomatic relief and limited improvement in cognitive functions. Many molecules have been explored that show promising outcomes in AD therapy and can regulate cellular survival through different pathways. To have a vivid approach to strategize the treatment regimen, AD physiopathology should be better explained considering diverse etiological factors in conjunction with biochemical disturbances. This Review attempts to discuss different disease modification approaches and address the novel therapeutic targets of AD that might pave the way for new drug discovery using the well-defined targets for therapy of the disease.

Details

ISSN :
25759108
Volume :
3
Database :
OpenAIRE
Journal :
ACS Pharmacology & Translational Science
Accession number :
edsair.doi.dedup.....975fb55797abb8b01ef37d9aca536676