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The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum
- Source :
- Experimental neurology. 151(2)
- Publication Year :
- 1998
-
Abstract
- Testosterone reversed the age-related increase in glial fibrillary acidic protein (GFAP) in the male rat cerebellum, a brain region not generally associated with gonadal steroid hormone sensitivity. This supports the hypothesis that a decrease in circulating testosterone contributes to age-related increase in GFAP. These data also suggest that reductions in circulating gonadal steroids during aging could render the brain more susceptible to neurodegeneration and that hormone replacement therapy might have value in neurodegenerative disease intervention.
- Subjects :
- Male
medicine.medical_specialty
Cerebellum
Aging
Antineoplastic Agents, Hormonal
medicine.medical_treatment
Central nervous system
Gene Expression
Developmental Neuroscience
Internal medicine
Glial Fibrillary Acidic Protein
medicine
Animals
Testosterone
Hormone replacement therapy
Glial fibrillary acidic protein
biology
Neurodegeneration
medicine.disease
Rats, Inbred F344
Rats
Steroid hormone
medicine.anatomical_structure
Endocrinology
nervous system
Neurology
Astrocytes
biology.protein
Astrocyte
Subjects
Details
- ISSN :
- 00144886
- Volume :
- 151
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Experimental neurology
- Accession number :
- edsair.doi.dedup.....975c85bfc8152459c1e4827e4978c95d