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Proinsulin C-peptide activates vagus efferent output in rats
- Source :
- Peptides. 26:2547-2553
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- The aim of this study was to examine the effect of proinsulin C-peptide on the autonomic nervous systems in rats. Intravenous administration of C-peptide gradually increased electrophysiological activity of the vagus nerves into the stomach and pancreas for at least 90 min. It also slightly increased gastric acid secretion that was suppressed by the treatment with atropine. Intraperitoneal injection of C-peptide did not affect the basal and stress-induced norepinephrine turnover rate, a biochemical index of sympathetic nerve activity. These results indicate that C-peptide increases parasympathetic nerve activity without affecting sympathetic nerve activity. This could explain, at least in part, the ameliorating effects of C-peptide on impaired cardiac autonomic nerve functions in patients with type 1 diabetes.<br />http://www.sciencedirect.com/science/journal/01969781
- Subjects :
- medicine.medical_specialty
Sympathetic nervous system
Sympathetic Nervous System
Physiology
atropine
vagus
Biology
Biochemistry
norepinephrine
Gastric Acid
Cellular and Molecular Neuroscience
Parasympathetic nervous system
chemistry.chemical_compound
parasympathetic nerve
Endocrinology
Internal medicine
medicine
Animals
Humans
Rats, Wistar
Vagal tone
sympathetic nerve
Proinsulin
Autonomic nerve
C-Peptide
C-peptide
Myocardium
Stomach
Heart
Vagus Nerve
Rats
Autonomic nervous system
Diabetes Mellitus, Type 1
medicine.anatomical_structure
chemistry
Gastric Mucosa
Injections, Intravenous
Gastric acid
Female
Subjects
Details
- ISSN :
- 01969781
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....9755dc883e9fc96961345f74b5f15c85