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Highly Sensitive MoS2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site
- Source :
- Nano-Micro Letters, Vol 10, Iss 3, Pp 1-12 (2018)
- Publication Year :
- 2018
- Publisher :
- SpringerOpen, 2018.
-
Abstract
- Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS2–ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.
- Subjects :
- Brain glioma
Materials science
Biocompatibility
genetic structures
Photoacoustic imaging in biomedicine
Molecular imaging
02 engineering and technology
010402 general chemistry
01 natural sciences
lcsh:Technology
chemistry.chemical_compound
In vivo
Glioma
medicine
Electrical and Electronic Engineering
Orthotopic brain glioma
MoS2–ICG hybrid
lcsh:T
Photothermal therapy
021001 nanoscience & nanotechnology
medicine.disease
eye diseases
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry
Photoacoustic imaging
0210 nano-technology
Indocyanine green
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 21505551 and 23116706
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Nano-Micro Letters
- Accession number :
- edsair.doi.dedup.....975343a9e9e78b9fc10ed81eeec92457