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A novel overlap syndrome: systemic sclerosis associated with antiphospholipid syndrome--a case series
- Source :
- Annals of the New York Academy of Sciences. 1108
- Publication Year :
- 2007
-
Abstract
- Antiphospholipid syndrome (APS) can be either primary or secondary to autoimmune diseases, malignancies, infectious diseases, or drug-induced conditions. The aim of this study was to describe a novel overlap syndrome of APS and systemic sclerosis (SSc) in a case series. A retrospective review of medical files of hospitalized patients who were followed in two rheumatology clinics in Israel for the diagnosis of SSc and APS was sought. A MEDLINE search was performed for reports of APS/SSc overlap syndrome. Five patients with the overlap syndrome of APS and SSc were retrieved. The diagnosis of both diseases was confirmed by the American College of Rheumatology classification criteria. Four patients were women and of an older age group (42-68 years old). Three patients had primary APS, and in two patients APS was secondary to SSc. Two of the five patients died. The interval between APS and SSc was < 1-18 years. APS/SSc overlap syndrome is described for the first time as a case series. The patients may be older, with an interval of up to 18 years between diseases. The APS patients did not suffer from SLE. The overlap syndrome was characterized in certain instances with severe disease and two patients died. With relevant clinical manifestations, APS should be sought in SSc patients and treated appropriately.
- Subjects :
- Adult
medicine.medical_specialty
Pediatrics
Hospitalized patients
Severe disease
General Biochemistry, Genetics and Molecular Biology
Fatal Outcome
History and Philosophy of Science
Antiphospholipid syndrome
Internal medicine
Medicine
Humans
skin and connective tissue diseases
Aged
Retrospective review
Scleroderma, Systemic
integumentary system
business.industry
General Neuroscience
Overlap syndrome
Middle Aged
medicine.disease
Antiphospholipid Syndrome
Rheumatology
Physical therapy
Anti-cardiolipin antibodies
Anticardiolipin antibodies
Female
business
Subjects
Details
- ISSN :
- 00778923
- Volume :
- 1108
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences
- Accession number :
- edsair.doi.dedup.....97386772be95b45a893ead929c8874dd