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Human Papillomavirus Infection in Papillomas and Nondiseased Respiratory Sites of Patients With Recurrent Respiratory Papillomatosis Using the Polymerase Chain Reaction
- Source :
- Archives of Otolaryngology - Head and Neck Surgery. 119:554-557
- Publication Year :
- 1993
- Publisher :
- American Medical Association (AMA), 1993.
-
Abstract
- • We examined human papillomavirus (HPV) infection in biopsy specimens and cellular scrapes that were taken from respiratory papillomas and six nondiseased sites from the respiratory tract of seven patients. Human papillomavirus was detected by polymerase chain reaction amplification, followed by DNA hybridization with probes for specific HPV types. All papillomas (100.0%, n=5) were positive only for HPV type 6 or 11. In the nondiseased site specimens, 61.3% (19/31) of the specimens were positive, again only for HPV type 6 or 11. Among the nondiseased site specimens from the cervical trachea, intrathoracic trachea, and bronchus, 80% to 100% were HPV positive compared with only 25% to 50% of HPV infection detected in the nasopharynx, posterior tonsillar pillar, and aryepiglottic fold. These results support the tenet that HPV infection is present in clinically normal respiratory tract tissue and that the reservoir site of reinfection is more commonly in the lower airway. However, patients with upper-airway involvement were more likely to be diagnosed as having severe disease. ( Arch Otolaryngol Head Neck Surg. 1993;119:554-557)
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Palatine Tonsil
Respiratory System
Bronchi
Papillomatosis
Polymerase Chain Reaction
Neoplasms, Multiple Primary
Nasopharynx
medicine
Humans
Papillomaviridae
Child
Bronchus
Papilloma
biology
business.industry
Respiratory disease
HPV infection
virus diseases
General Medicine
respiratory system
biology.organism_classification
medicine.disease
Respiratory Tract Neoplasms
Trachea
Tumor Virus Infections
medicine.anatomical_structure
Otorhinolaryngology
Child, Preschool
DNA, Viral
Female
Surgery
Larynx
Neoplasm Recurrence, Local
medicine.symptom
Recurrent Respiratory Papillomatosis
business
Follow-Up Studies
Respiratory tract
Subjects
Details
- ISSN :
- 08864470
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Archives of Otolaryngology - Head and Neck Surgery
- Accession number :
- edsair.doi.dedup.....97358ee717646f195b524b043bfc9b3d