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Supplementary Figure S1 to S6 and Supplementary Materials and Methods from Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody–Drug Conjugate

Authors :
Toshinori Agatsuma
George D. Demetri
Atsushi Ochiai
Toshihiko Doi
Suzanne George
Matthew L. Hemming
Sandro Santagata
Jessica L. Andersen
Taisei Nomura
Yuki Abe
Reiko Kamei
Koichiro Inaki
Takashi Nakada
Tsuyoshi Karibe
Takuma Iguchi
Jun Hasegawa
Manabu Abe
Chiharu Hattori
Michiko Kitamura
Satoru Yasuda
Tomoko Shibutani
Akiko Kawano Nagatsuma
Amr H. Abdelhamid Ahmed
Kenji Iida
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

S1: Expression of GPR20 in clinical GIST specimens from NCCHE S2: Representative images of GPR20 expression in various sarcoma including GIST in University of Basel derived TMA. S3: GPR20 was not expressed in systemic mastocytosis. S4: Protein expression of human, cynomolgus monkey, rat, and mouse GPR20 on CHO-K1 cells. S5: Lack of DS-6157a efficacy in the GPR20-negative KPL-4 xenograft model. S6: Comparison of tumor growth curve of GIST-T1 and GIST-T1/GPR20 xenograft models.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....972e3baf460726f896fad4d66dcaea01