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Impact of cardiovascular risk factors on the clinical presentation and survival of pulmonary embolism without identifiable risk factor
- Source :
- J Thorac Dis
- Publication Year :
- 2020
- Publisher :
- AME Publishing Company, 2020.
-
Abstract
- Background: The nature of pulmonary embolism (PE) without identifiable risk factor (IRF) remains unclear. The objective of this study is to investigate the potential relationship between cardiovascular risk factors (CVRFs) and PE without IRF (unprovoked) and assess their role as markers of disease severity and prognosis. Methods: A case-control study was performed of patients with PE admitted to our hospital [2010-2019]. Subjects with PE without IRF were included in the cohort of cases, whereas patients with PE with IRF were allocated to the control group. Variables of interest included age, active smoking, obesity, and diagnosis of arterial hypertension, dyslipidemia or diabetes mellitus. Results: A total of 1,166 patients were included in the study, of whom 64.2% had PE without IRF. The risk for PE without IRF increased with age [odds ratio (OR): 2.68; 95% confidence interval (CI): 1.95-3.68], arterial hypertension (OR: 1.63; 95% CI: 1.27-2.07), and dyslipidemia (OR: 1.63; 95% CI: 1.24-2.15). The risk for PE without IRF was higher as the number of CVRF increased, being 3.99 (95% CI: 2.02-7.90) for subjects with ≥3 CVRF. The percentage of high-risk unprovoked PE increased significantly as the number of CVRF rose [0.6% for no CVRF; 23.8% for a CRF, P
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
business.industry
Odds ratio
030204 cardiovascular system & hematology
medicine.disease
Obesity
Confidence interval
Pulmonary embolism
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
Cohort
medicine
Original Article
030212 general & internal medicine
Risk factor
business
Dyslipidemia
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J Thorac Dis
- Accession number :
- edsair.doi.dedup.....9723d0cee61332ca7366fcbba46fb41b