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Cerebral Imaging Markers of GBA and LRRK2 Related Parkinson's Disease and Their First-Degree Unaffected Relatives
- Source :
- Brain topography. 31(6)
- Publication Year :
- 2018
-
Abstract
- Cerebral atrophy has been detected in patients with Parkinson’s disease (PD) both with and without dementia, however differentiation based on genetic status has thus far not yielded robust findings. We assessed cortical thickness and subcortical volumes in a cohort of PD patients and healthy controls carriers of the G2019S mutation in the LRRK2 gene and the common GBA mutations, in an attempt to determine whether genetic status influences structural indexes. Cortical thickness and subcortical volumes were computed and compared between six groups of participants; idiopathic PD, GBA-PD, LRRK2-PD, non-manifesting non-carriers (NMNC), GBA-non-manifesting carriers (NMC) and LRRK2-NMC utilizing the FreeSurfer software program. All participants were cognitively intact based on a computerized cognitive assessment battery. Fifty-seven idiopathic PD patients, 9 LRRK2-PD, 12 GBA-PD, 49 NMNC, 41 LRRK2-NMC and 14 GBA-NMC participated in this study. Lower volumes among patients with PD compared to unaffected participants were detected in bilateral hippocampus, nucleus accumbens, caudate, thalamus, putamen and amygdala and the right pallidum (p = 0.016). PD patients demonstrated lower cortical thickness indexes in a majority of regions assessed compared with non-manifesting participants. No differences in cortical thickness and subcortical volumes were detected within each of the groups of participants based on genetic status. Mutations in the GBA and LRRK2 genes are not important determinants of cortical thickness and subcortical volumes in both patients with PD and non-manifesting participants. PD is associated with a general reduction in cortical thickness and sub-cortical atrophy even in cognitively intact patients.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Neurology
Parkinson's disease
Thalamus
Hippocampus
Globus Pallidus
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Nucleus Accumbens
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Atrophy
Internal medicine
medicine
Dementia
Humans
Radiology, Nuclear Medicine and imaging
Family
Aged
Cerebral atrophy
Cerebral Cortex
Radiological and Ultrasound Technology
business.industry
Putamen
Brain
Parkinson Disease
Organ Size
Middle Aged
medicine.disease
Amygdala
030104 developmental biology
Case-Control Studies
Mutation
Cardiology
Glucosylceramidase
Female
Neurology (clinical)
Anatomy
Caudate Nucleus
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 15736792
- Volume :
- 31
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Brain topography
- Accession number :
- edsair.doi.dedup.....97225c32af7d9dc4a2a4bb099b6b40e0