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Behavioral and Accumbal Responses During an Affective Go/No-Go Task Predict Adherence to Injectable Naltrexone Treatment in Opioid Use Disorder
- Source :
- International Journal of Neuropsychopharmacology
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Adherence is a major factor in the effectiveness of the injectable extended-release naltrexone as a relapse prevention treatment in opioid use disorder. We examined the value of a variant of the Go/No-go paradigm in predicting extended-release naltrexone adherence in 27 detoxified opioid use disorder patients who were offered up to 3 monthly extended-release naltrexone injections. Before extended-release naltrexone, participants performed a Go/No-go task that comprised positively valenced Go trials and negatively valenced No-go trials during a functional magnetic resonance imaging scan. Errors of commission and neural responses to the No-go vs Go trials were independent variables. Adherence, operationalized as the completion of all 3 extended-release naltrexone injections, was the outcome variable. Fewer errors of commission and greater left accumbal response during the No-go vs Go trials predicted better adherence. These findings support the clinical potential of the behavioral and neurophysiological correlates of response inhibition in the prediction of extended-release naltrexone treatment outcomes in opioid use disorder.
- Subjects :
- Adult
Male
Adolescent
nucleus accumbens
Narcotic Antagonists
Treatment outcome
Relapse prevention
Injections, Intramuscular
Naltrexone
Medication Adherence
Task (project management)
Young Adult
extended-release naltrexone
03 medical and health sciences
0302 clinical medicine
Outcome variable
Predictive Value of Tests
medicine
Humans
Pharmacology (medical)
adherence
030304 developmental biology
Pharmacology
0303 health sciences
medicine.diagnostic_test
business.industry
Brief Report
opioid use disorder
Opioid use disorder
Opioid-Related Disorders
medicine.disease
Magnetic Resonance Imaging
3. Good health
Editor's Choice
Psychiatry and Mental health
Treatment Outcome
Delayed-Action Preparations
Go/no go
Female
errors of commission
Functional magnetic resonance imaging
business
Photic Stimulation
Psychomotor Performance
030217 neurology & neurosurgery
medicine.drug
Clinical psychology
Subjects
Details
- ISSN :
- 14695111 and 14611457
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- International Journal of Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....971e331c9ed0d00fc8f49f08b1b57d33