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Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel
- Source :
- MATEC Web of Conferences, Vol 333, p 11008 (2021)
- Publication Year :
- 2021
- Publisher :
- EDP Sciences, 2021.
-
Abstract
- Hydrogels have become popular as drug carriers. Controlled release of the drugs from hydrogels can reduce dosage, inducing prevention of side effects. However, the hydrophilicity of hydrogels interferes with controlled release of hydrophobic drugs such as anticancer agents or antibiotics. In this study, we developed hydrophobically-modified gelatin (HMG) hydrogel, which was cross-linked only by hydrophobic interaction. HMG does not require toxic chemical cross-linkers to form hydrogel. In addition, the HMG hydrogel has hydrophobic chambers in its structure which hydrophobic drugs can adsorb to and desorb from. In order to control the amount of hydrophobic drugs adsorbed into the hydrogel, hydrophobic alkyl chains with different lengths (C4-C12) were incorporated into gelatin molecules. Uranine was used as a model for hydrophobic drugs. The adsorption test exhibited that the amount of uranine adsorbed in HMG hydrogels could be controlled by varying hydrophobic alkyl chain length and that the drug could be released in a controlled manner. These results show that HMG hydrogels are promising carriers of hydrophobic drugs.
- Subjects :
- chemistry.chemical_classification
food.ingredient
Hydrophobic drug
technology, industry, and agriculture
02 engineering and technology
macromolecular substances
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Gelatin
complex mixtures
0104 chemical sciences
Chain length
food
Adsorption
chemistry
Chemical engineering
lcsh:TA1-2040
0210 nano-technology
lcsh:Engineering (General). Civil engineering (General)
Alkyl
Subjects
Details
- Language :
- English
- Volume :
- 333
- Database :
- OpenAIRE
- Journal :
- MATEC Web of Conferences
- Accession number :
- edsair.doi.dedup.....971c5c8567613d4130fb55ab34e7055a