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Effect of Alkyl Chain Length on Adsorption and Release of Hydrophobic Drug to/from Hydrophobically-modified Gelatin Hydrogel

Authors :
Masahiro Yoshida
Yoshiki Fukuhara
Yshihiro Ohzuno
Takayuki Takei
Source :
MATEC Web of Conferences, Vol 333, p 11008 (2021)
Publication Year :
2021
Publisher :
EDP Sciences, 2021.

Abstract

Hydrogels have become popular as drug carriers. Controlled release of the drugs from hydrogels can reduce dosage, inducing prevention of side effects. However, the hydrophilicity of hydrogels interferes with controlled release of hydrophobic drugs such as anticancer agents or antibiotics. In this study, we developed hydrophobically-modified gelatin (HMG) hydrogel, which was cross-linked only by hydrophobic interaction. HMG does not require toxic chemical cross-linkers to form hydrogel. In addition, the HMG hydrogel has hydrophobic chambers in its structure which hydrophobic drugs can adsorb to and desorb from. In order to control the amount of hydrophobic drugs adsorbed into the hydrogel, hydrophobic alkyl chains with different lengths (C4-C12) were incorporated into gelatin molecules. Uranine was used as a model for hydrophobic drugs. The adsorption test exhibited that the amount of uranine adsorbed in HMG hydrogels could be controlled by varying hydrophobic alkyl chain length and that the drug could be released in a controlled manner. These results show that HMG hydrogels are promising carriers of hydrophobic drugs.

Details

Language :
English
Volume :
333
Database :
OpenAIRE
Journal :
MATEC Web of Conferences
Accession number :
edsair.doi.dedup.....971c5c8567613d4130fb55ab34e7055a