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Visit-to-visit blood pressure variability and hip fracture risk in older persons
- Source :
- Osteoporosis International. 30:763-770
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- We investigated the association between blood pressure variability measured by the coefficient of variation (CV) of blood pressure and hip fracture in older persons with diabetes. After excluding patients with acute complications and comorbidities, a positive association with similar magnitude of strength was found between BP variability and hip fracture, compared with that in the original analysis. Hypertension is a risk factor of osteoporosis and hip fracture, but studies have yet to investigate whether blood pressure variability measured by the CV of blood pressure can predict hip fracture in older persons with diabetes. We conducted a retrospective cohort study on 21,160 patients who suffered from type 2 diabetes (age ≥ 50 years) and participated in the National Diabetes Care Management Program in Taiwan. The patients’ 1-year variability in systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the baseline and subsequent hip fracture incidence for 8.2 years were analyzed. There were 937 recorded incident hip fractures. SBP-CV and DBP-CV were classified based on their tertiles. After multivariate adjustment was conducted, SBP-CV found to be a predictor of hip fracture, and its hazard ratio was 1.18 (95% CI 1.00–1.40) for the third tertile compared with the first tertile. Our study suggests SBP stability is a predictor for hip fracture incidence in older persons with type 2 diabetes.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Osteoporosis
Taiwan
Blood Pressure
030209 endocrinology & metabolism
Type 2 diabetes
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Humans
Risk factor
Aged
Retrospective Studies
Hip fracture
Hip Fractures
business.industry
Hazard ratio
Retrospective cohort study
Middle Aged
medicine.disease
Blood pressure
Diabetes Mellitus, Type 2
Hypertension
Female
030101 anatomy & morphology
business
Osteoporotic Fractures
Subjects
Details
- ISSN :
- 14332965 and 0937941X
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Osteoporosis International
- Accession number :
- edsair.doi.dedup.....97119463269f85fbc8a753f942317392