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Molecular Classification of Renal Cell Carcinoma and Its Implication in Future Clinical Practice
- Source :
- Kidney Cancer
- Publication Year :
- 2017
- Publisher :
- IOS Press, 2017.
-
Abstract
- Renal cell carcinoma (RCC) encompasses a wide spectrum of morphologically and molecularly distinct (>10) cancer subtypes originated from the kidney epithelium. Metastatic RCC (mRCC) is lethal and refractory to conventional chemotherapeutic agents. The incorporation of targeted therapies and immune checkpoint inhibitors into the current practice of mRCC has markedly improved the median overall survival of clear cell RCC (ccRCC) patients, the most common subtype, but not rare kidney cancer (RKC or non-ccRCC, nccRCC). Varied treatment response in mRCC patients is observed, which presents clinical challenges/opportunities at the modern mRCC therapeutic landscape consisting of 12 approved drugs representing 6 different effective mechanisms. Key contributing factors include inter- and intra-RCC heterogeneity. With the advances in pan-omics technologies, we now have a better understanding of the molecular pathobiology of individual RCC subtype. Here, we attempt to classify ccRCC based on contemporary molecular features with emphasis on their respective potential significance in clinical practice.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
precision medicine
Review
urologic and male genital diseases
03 medical and health sciences
transcriptomics
0302 clinical medicine
Molecular classification
proteomics
Renal cell carcinoma
Internal medicine
medicine
genomics
therapeutics
Kidney
molecular classification
business.industry
Cancer
biomarkers
Kidney cancer
medicine.disease
Precision medicine
metabolomics
Clinical Practice
030104 developmental biology
medicine.anatomical_structure
Nephrology
030220 oncology & carcinogenesis
business
Clear cell
Subjects
Details
- Language :
- English
- ISSN :
- 24684570 and 24684562
- Volume :
- 1
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Kidney Cancer
- Accession number :
- edsair.doi.dedup.....970f38fa19052732cb96b99c030887cc