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The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment
- Source :
- EMBO molecular medicine, 8 (8, EMBO Molecular Medicine, EMBO Molecular Medicine, Vol. 8, No 8 (2016) pp. 937-48, EMBO Molecular Medicine, 8(8), 937-948. Wiley-Blackwell, EMBO molecular medicine, 8(8), 937-948. Wiley-Blackwell
- Publication Year :
- 2016
-
Abstract
- Myocardial infarction (MI) is the leading cause of death in Western countries. Epidemiological studies show acute MI to be more prevalent in the morning and to be associated with a poorer outcome in terms of mortality and recovery. The mechanisms behind this association are not fully understood. Here, we report that circadian oscillations of neutrophil recruitment to the heart determine infarct size, healing, and cardiac function after MI Preferential cardiac neutrophil recruitment during the active phase (Zeitgeber time, ZT13) was paralleled by enhanced myeloid progenitor production, increased circulating numbers of CXCR2(hi) neutrophils as well as upregulated cardiac adhesion molecule and chemokine expression. MI at ZT13 resulted in significantly higher cardiac neutrophil infiltration compared to ZT5, which was inhibited by CXCR2 antagonism or neutrophil-specific CXCR2 knockout. Limiting exaggerated neutrophilic inflammation at this time point significantly reduced the infarct size and improved cardiac function.<br />info:eu-repo/semantics/published
- Subjects :
- 0301 basic medicine
Chemokines -- metabolism
Chemokine
Myeloid
Myocardial Infarction
ddc:616.07
Inbred C57BL
Cardiovascular System
Mice
neutrophils
Fibrosis
CXC chemokine receptors
Myocardial infarction
Research Articles
Cause of death
biology
Sciences bio-médicales et agricoles
Chemokines/metabolism
3. Good health
medicine.anatomical_structure
Neutrophil Infiltration
Cardiology
cardiovascular system
Molecular Medicine
Female
Chemokines
Research Article
Cardiac function curve
circadian rhythm
medicine.medical_specialty
Immunology
Myocardial Infarction -- pathology -- physiopathology
03 medical and health sciences
Internal medicine
medicine
Animals
Progenitor cell
progenitors
Myocardial Infarction/pathology/physiopathology
Animal
business.industry
fibrosis
medicine.disease
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
myocardial infarction healing
Cardiovascular and Metabolic Diseases
Disease Models
biology.protein
business
Subjects
Details
- Language :
- English
- ISSN :
- 17574676 and 17574684
- Database :
- OpenAIRE
- Journal :
- EMBO molecular medicine, 8 (8, EMBO Molecular Medicine, EMBO Molecular Medicine, Vol. 8, No 8 (2016) pp. 937-48, EMBO Molecular Medicine, 8(8), 937-948. Wiley-Blackwell, EMBO molecular medicine, 8(8), 937-948. Wiley-Blackwell
- Accession number :
- edsair.doi.dedup.....97098bb226dc7068f13e1d7dc1021fc5