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Modified single prolonged stress reduces cocaine self-administration during acquisition regardless of rearing environment
- Source :
- Behavioural Brain Research. 338:143-152
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Until recently, there were few rodent models available to study the interaction of post-traumatic stress disorder (PTSD) and drug taking. Like PTSD, single prolonged stress (SPS) produces hypothalamic-pituitary-adrenal (HPA) axis dysfunction and alters psychostimulant self-administration. Other stressors, such as isolation stress, also alter psychostimulant self-administration. However, it is currently unknown if isolation housing combined with SPS can alter the acquisition or maintenance of cocaine self-administration. The current study applied modified SPS (modSPS; two hours restraint immediately followed by cold swim stress) to rats raised in an isolation condition (Iso), enrichment condition (Enr), or standard condition (Std) to measure changes in cocaine self-administration and HPA markers. Regardless of rearing condition, rats exposed to modSPS had greater corticosterone (CORT) release and reduced cocaine self-administration during initial acquisition compared to non-stressed controls. In addition, during initial acquisition, rats that received both Iso rearing and modSPS showed a more rapid increase in cocaine self-administration across sessions compared to Enr and Std rats exposed to modSPS. Following initial acquisition, a dose response analysis showed that Iso rats were overall most sensitive to changes in cocaine unit dose; however, modSPS had no effect on the cocaine dose response curve. Further, there was no effect of either modSPS or differential rearing on expression of glucocorticoid receptor (GR) in hypothalamus, medial prefrontal cortex, amygdala, or nucleus accumbens. By using modSPS in combination with Iso housing, this study identified unique contributions of each stressor to acquisition of cocaine self-administration.
- Subjects :
- Male
Restraint, Physical
0301 basic medicine
medicine.medical_specialty
Prefrontal Cortex
Self Administration
Nucleus accumbens
Amygdala
Nucleus Accumbens
Article
Rats, Sprague-Dawley
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
Receptors, Glucocorticoid
0302 clinical medicine
Cocaine
Dopamine Uptake Inhibitors
Corticosterone
Internal medicine
medicine
Animals
Psychiatry
Prefrontal cortex
Environmental enrichment
Housing, Animal
Rats
Dose–response relationship
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Social Isolation
chemistry
Hypothalamus
Self-administration
Psychology
Stress, Psychological
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01664328
- Volume :
- 338
- Database :
- OpenAIRE
- Journal :
- Behavioural Brain Research
- Accession number :
- edsair.doi.dedup.....9703414c872a768df8108158732b1dfe