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Metabolomics in Parkinson's disease
- Source :
- Advances in Clinical Chemistry ISBN: 9780128246221, info:cnr-pdr/source/autori:Troisi J.; Landolfi A.; Cavallo P.; Marciano F.; Barone P.; Amboni M./titolo:Metabolomics in Parkinson's disease/titolo_volume:/curatori_volume:/editore:/anno:2020
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Parkinson's disease (PD) is a multifactorial neurodegenerative disorder in which environmental (lifestyle, dietary, infectious disease) factors as well as genetic make-up play a role. Metabolomics, an evolving research field combining biomarker discovery and pathogenetics, is particularly useful in studying complex pathophysiology in general and Parkinson's disease (PD) specifically. PD, the second most frequent neurodegenerative disorder, is characterized by the loss of dopaminergic neurons in the substantia nigra and the presence of intraneural inclusions of ?-synuclein aggregates. Although considered a predominantly movement disorder, PD is also associated with number of non-motor features. Metabolomics has provided useful information regarding this neurodegenerative process with the aim of identifying a disease-specific fingerprint. Unfortunately, many disease variables such as clinical presentation, motor system involvement, disease stage and duration substantially affect biomarker relevance. As such, metabolomics provides a unique approach to studying this multifactorial neurodegenerative disorder.
- Subjects :
- Glucocerebrosidase
Alpha-synuclein
Parkinson's disease
Mass spectrometry
business.industry
alpha-synuclein
Substantia nigra
Disease
medicine.disease
Biomarker (cell)
chemistry.chemical_compound
chemistry
Oxidative stress
Infectious disease (medical specialty)
Metabolomics
Medicine
Biomarker discovery
business
Metabolomics: Parkinson's disease
Neuroscience
Subjects
Details
- ISBN :
- 978-0-12-824622-1
- ISBNs :
- 9780128246221
- Database :
- OpenAIRE
- Journal :
- Advances in Clinical Chemistry ISBN: 9780128246221, info:cnr-pdr/source/autori:Troisi J.; Landolfi A.; Cavallo P.; Marciano F.; Barone P.; Amboni M./titolo:Metabolomics in Parkinson's disease/titolo_volume:/curatori_volume:/editore:/anno:2020
- Accession number :
- edsair.doi.dedup.....97030606f9942d51b4f0672697f1e02e