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An interim analysis of non-interventional study of the epidemiology and natural history of non-metastatic castration-resistant prostate cancer in Russia
- Source :
- Onkourologiâ, Vol 16, Iss 3, Pp 90-101 (2020)
- Publication Year :
- 2020
- Publisher :
- ABV-press, 2020.
-
Abstract
- Objective: to study the clinical and demographic profile of patients with non-metatstatic castration-resistant prostate cancer (nmCRPC) and clinical approaches to the treatment of nmCRPC in the context of daily medical practice before and after progression M1 stage.Materials and methods. The multicenter non-interventional epidemiological study is planned to include 200 patients with a documented diagnosis of nmCRPC from 2019 to 2020. The interim report has included data on 108 patients from 13 centers located in different regions of the Russian Federation. The median age of the patients was 73 (55—90) years.Results and conclusion. When the diagnosis of nmCRPC was made, the median prostate specific antigen was 8.23 (0.17—116.9) ng/ml, and the prostate specific antigen doubling time was 6 (1—50) months. When diagnosed nmCRPC, 86 patients (79.6 %) underwent a change of therapy, of which 42 % were prescribed modern regimens containing the new generation non-steroid antiandrogens (apalutamide, enzalutamide).
- Subjects :
- medicine.medical_specialty
non-metastatic castration-resistant prostate cancer
genetic structures
Urology
Context (language use)
androgen deprivation therapy
new generation antiandrogen
Androgen deprivation therapy
03 medical and health sciences
chemistry.chemical_compound
Prostate cancer
0302 clinical medicine
Internal medicine
Epidemiology
medicine
Enzalutamide
Radiology, Nuclear Medicine and imaging
030212 general & internal medicine
Stage (cooking)
business.industry
Apalutamide
prostate-specific antigen doubling time
medicine.disease
Prostate-specific antigen
Oncology
chemistry
Nephrology
030220 oncology & carcinogenesis
Medicine
Surgery
business
Subjects
Details
- Language :
- Russian
- ISSN :
- 19961812 and 17269776
- Volume :
- 16
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Onkourologiâ
- Accession number :
- edsair.doi.dedup.....96fefe05980e826112787f54f21448b7