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A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases
- Source :
- Theranostics
- Publication Year :
- 2020
- Publisher :
- Ivyspring International Publisher, 2020.
-
Abstract
- Metabolic syndrome (MTS) is a cluster of concurrent metabolic abnormal conditions. MTS and its component metabolic diseases are heterogeneous and closely related, making their relationships complicated, thus hindering precision treatment. Methods: We collected seven groups of samples (group a: healthy individuals; group b: obesity; group c: MTS; group d: hyperglycemia, group e: hypertension, group f: hyperlipidemia; group g: type II diabetes, n=7 for each group). We examined the molecular characteristics of each sample by metabolomic, proteomic and peptidomic profiling analysis. The differential molecules (including metabolites, proteins and peptides) between each disease group and the healthy group were recognized by statistical analyses. Furthermore, a two-step clustering workflow which combines multi-omics and clinical information was used to redefine molecularly and clinically differential groups. Meanwhile, molecular, clinical, network and pathway based analyses were used to identify the group-specific biological features. Results: Both shared and disease-specific molecular profiles among the six types of diseases were identified. Meanwhile, the patients were stratified into three distinct groups which were different from original disease definitions but presented significant differences in glucose and lipid metabolism (Group 1: relatively favorable metabolic conditions; Group 2: severe dyslipidemia; Group 3: dysregulated insulin and glucose). Group specific biological signatures were also systematically described. The dyslipidemia group showed higher levels in multiple lipid metabolites like phosphatidylserine and phosphatidylcholine, and showed significant up-regulations in lipid and amino acid metabolism pathways. The glucose dysregulated group showed higher levels in many polypeptides from proteins contributing to immune response. The another group, with better glucose/lipid metabolism ability, showed higher levels in lipid regulating enzymes like the lecithin cholesterol acyltransferase and proteins involved in complement and coagulation cascades. Conclusions: This multi-omics based study provides a general view of the complex relationships and an alternative classification for various metabolic diseases where the cross-talk or compensatory mechanism between the immune and metabolism systems plays a critical role.
- Subjects :
- Male
Proteomics
0301 basic medicine
multi-omics data
medicine.medical_treatment
Medicine (miscellaneous)
Hyperlipidemias
Phosphatidylserines
Biology
Bioinformatics
Group A
03 medical and health sciences
0302 clinical medicine
Metabolomics
Metabolic Diseases
Hyperlipidemia
medicine
Humans
Insulin
Obesity
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
lipid and glucose metabolism
Metabolic Syndrome
Lipid metabolism
Metabolism
Middle Aged
Lipid Metabolism
medicine.disease
Up-Regulation
Glucose
030104 developmental biology
Diabetes Mellitus, Type 2
Hyperglycemia
030220 oncology & carcinogenesis
disease subtype identification
Hypertension
Phosphatidylcholines
Female
Peptidomimetics
Metabolic syndrome
Dyslipidemia
Research Paper
Subjects
Details
- ISSN :
- 18387640
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Theranostics
- Accession number :
- edsair.doi.dedup.....96fc6e5cbfa4a32cda5dfc9f18f9972e