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Cyanide Bridged PlatinumāIron Complexes as Cisplatin Prodrug Systems: Design and Computational Study
- Source :
- ChemPhysChem. 22:106-111
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- The potential role of cyanide-bridged platinum-iron complexes as an anti-cancer Pt(IV) prodrug is studied. We present design principles of a dual-function prodrug that can upon reduction dissociate and release concurrently six cisplatin units and a ferricyanide anion per prodrug unit. The prodrug molecule is a unique complex of hepta metal centers consisting of a ferricyanide core with six Pt(IV) centers each bonded to the Fe(III) core through a cyano ligand. The functionality of the prodrug is addressed through density functional theory (DFT) calculations.
- Subjects :
- Iron
Cyanide
chemistry.chemical_element
Antineoplastic Agents
02 engineering and technology
Ligands
010402 general chemistry
01 natural sciences
Metal
chemistry.chemical_compound
Coordination Complexes
Molecule
Prodrugs
Physical and Theoretical Chemistry
Density Functional Theory
Platinum
Cyanides
Molecular Structure
Ligand
Prodrug
021001 nanoscience & nanotechnology
Combinatorial chemistry
Atomic and Molecular Physics, and Optics
0104 chemical sciences
chemistry
Drug Design
visual_art
visual_art.visual_art_medium
Density functional theory
Ferricyanide
Cisplatin
0210 nano-technology
Subjects
Details
- ISSN :
- 14397641 and 14394235
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- ChemPhysChem
- Accession number :
- edsair.doi.dedup.....96f9a69e052cb2d253361c706f077641