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High Incidence of HIV-1 Infection in a General Population of Fishing Communities around Lake Victoria, Uganda
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 5, p e94932 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- BACKGROUND: High HIV-1 incidence rates were reported among persons in fisherfolk communities (FFC) in Uganda who were selected for high risk behaviour. We assessed the incidence of HIV-1 and associated risk factors in a general population FFC to determine population-wide HIV rates. METHODS: A community-based cohort study was conducted among a random sample of 2191 participants aged 18-49 years. At baseline and 12 months post-baseline, data were collected on socio-demographic characteristics and risky behaviors (including number of partners, new partners, condom use, use of alcohol and illicit drug use). Venous blood was collected for HIV serological testing. HIV incidence was calculated per 100 person years at-risk (pyar) and adjusted incidence rate ratios (Adj.IRR) were estimated by multivariable Poisson regression. RESULTS: Overall follow up at 12 months was 76.9% (1685/2191) and was significantly higher among HIV uninfected persons and those with at least 1 year duration of stay in community. Overall HIV-1 incidence was 3.39/100 pyar (95% CI: 2.55-4.49). Among the 25-29 years who drank alcohol, HIV incidence was 7.67/100 pyar (95% CI;4.62-12.7) while it was 5.67/100 pyar (95% CI;3.14-10.2) for 18-24 year olds who drank alcohol. The risk of HIV infection was higher among 25-29 years (adj.IRR = 3.36; 95% CI: 1.48-7.65) and 18-24 years (adj.IRR = 2.65; 95% CI: 1.05-6.70) relative to 30+ years. Compared to non-drinkers, HIV incidence increased by frequency of alcohol drinking--occasional drinkers (adj.IRR = 3.18; 95% CI: 1.18-8.57) and regular drinkers (adj.IRR = 4.93; 95% CI: 1.91-12.8). CONCLUSION: HIV-1 incidence in general fisherfolk population along L. Victoria, Uganda, is high and is mainly associated with young age and alcohol drinking. HIV prevention and control strategies are urgently needed in this population.
- Subjects :
- Male
Viral Diseases
Epidemiology
Human immunodeficiency virus (HIV)
lcsh:Medicine
HIV Infections
medicine.disease_cause
Cohort Studies
Immunodeficiency Viruses
Risk Factors
Agency (sociology)
Medicine
Uganda
lcsh:Science
Family Characteristics
education.field_of_study
Multidisciplinary
Incidence
Incidence (epidemiology)
Middle Aged
Spatial epidemiology
Infectious Diseases
Medical Microbiology
HIV epidemiology
Research Design
Viral Pathogens
Physical Sciences
Female
International development
Statistics (Mathematics)
Research Article
Infectious disease epidemiology
Cohort study
Adult
Social epidemiology
Adolescent
Clinical Research Design
Population
Fishing
Fisheries
Developing country
Biostatistics
Research and Analysis Methods
Microbiology
Young Adult
Environmental health
Humans
education
Microbial Pathogens
Medicine and health sciences
business.industry
lcsh:R
Biology and Life Sciences
HIV
Lakes
HIV-1
lcsh:Q
business
Mathematics
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....96f861a1448d4a26a3a18481548062ab