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Kidney transplantation in patients with inflammatory bowel diseases ( <scp>IBD</scp> ): analysis of transplantation outcome and <scp>IBD</scp> activity
- Source :
- Transplant International. 32
- Publication Year :
- 2019
- Publisher :
- Frontiers Media SA, 2019.
-
Abstract
- Inflammatory bowel diseases (IBD) is a systemic disorder with possible renal involvement, yet data regarding the outcome of kidney transplantation (KT) in those patients, and IBD course post KT, are scarce. In this retrospective analysis, we studied the outcome of 12 IBD kidney recipients (seven Crohn's disease, five ulcerative colitis; primary kidney disease was IgA nephropathy in five, polycystic disease in four), compared to two control groups: matched controls and a cohort of recipients with similar kidney disease. During a follow-up period of 60.1 (11.0-76.6) months (median, interquartile range), estimated 5-year survival was 80.8 vs. 96.8%, with and without IBD, respectively (P = 0.001). Risk of death with a functioning graft was higher with IBD (HR = 1.441, P = 0.048), and with increased age (HR = 1.109, P = 0.05). Late rehospitalization rate was higher in IBD [incidence rate ratio = 1.168, P = 0.030], as well as rate of hospitalization related to infection [1.42, P = 0.037]. All patients that were in remission before KT, remission was maintained. Patients that were transplanted with mild or moderate disease remained stable or improved with Infliximab or Adalimumab treatment. In conclusion, IBD is associated with an increased risk of mortality, hospitalization because of infection and late rehospitalization after KT. Clinical course of IBD is stable after KT.
- Subjects :
- Adult
Male
medicine.medical_specialty
030230 surgery
Patient Readmission
Gastroenterology
Inflammatory bowel disease
Nephropathy
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Adalimumab
Humans
Medicine
Kidney transplantation
Aged
Retrospective Studies
Immunosuppression Therapy
Polycystic Kidney Diseases
Transplantation
business.industry
Glomerulonephritis, IGA
Middle Aged
Inflammatory Bowel Diseases
medicine.disease
Kidney Transplantation
Ulcerative colitis
Infliximab
digestive system diseases
Hospitalization
Treatment Outcome
Kidney Failure, Chronic
Female
030211 gastroenterology & hepatology
business
Follow-Up Studies
Glomerular Filtration Rate
medicine.drug
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 09340874 and 14322277
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Transplant International
- Accession number :
- edsair.doi.dedup.....96f4fa4a66bce47388a9a55ed847b059
- Full Text :
- https://doi.org/10.1111/tri.13415