Effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Supplementation on Nutritional and Metabolic Parameters in the Early Postoperative Period after Roux-en-Y Gastric Bypass: a Randomized, Double-Blind, Placebo-Controlled Trial

Made available in DSpace on 2021-06-25T10:49:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 Abstract: Studies have suggested that Roux-en-Y gastric bypass (RYGB) causes changes in the intestinal microbiota composition and function due to anatomical and physiological modifications. The role of probiotic supplementation after bariatric procedures remains to be determined. Purpose: The aim of this study was to investigate the effects of Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 supplementation on nutritional and metabolic parameters after RYGB. Materials and Methods: This is a randomized, double-blind, placebo-controlled clinical trial. Patients were assigned to receive either a probiotic supplement (FloraVantage®) or placebo for three consecutive months, beginning 7 days after surgery. Anthropometric and biochemical indexes were evaluated in the preoperative period and at the end of the study. Results: Following RYGB, serum 25-OH vitamin D increased in both groups compared to baseline; however, this increase was significant only in the probiotic group (p = 0.004). Vitamin B12 levels tended to be higher in the probiotic group compared to the placebo group (p = 0.063), and triglyceride levels showed a significant reduction in the probiotic group only (p < 0.001). In addition, a significant reduction was observed in the anthropometric parameters and glycemic profile (p < 0.05) in both groups. Conclusion: Probiotic supplementation after RYGB improves the vitamin and lipid profile. UFPR Post-graduate Program in Clinical Surgery Surgery Department – Hospital of Clinics Federal University of Paraná, R. Gen. Carneiro, 49 - Alto da Glória, Curitiba -PR School of Medicine Department of Pathology São Paulo State University (UNESP) Nutrition Course of the Pontifical Catholic University of Paraná (PUCPR) Department of Statistics Federal University of Paraná Statistics and Agricultural Experimentation ESALQ-USP Faculty of Health Sciences Federal University of Grande Dourados Santa Casa de Misericórdia de Curitiba Hospital Post-graduate Program in Clinical Surgery Surgery Department Federal University of Parana School of Medicine Department of Pathology São Paulo State University (UNESP)