Back to Search
Start Over
Genome-scale meta-analysis of breast cancer datasets identifies promising targets for drug development
- Source :
- Journal of Biological Research-Thessaloniki, Vol 28, Iss 1, Pp 1-15 (2021), Journal of Biological Research
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Because of the highly heterogeneous nature of breast cancer, each subtype differs in response to several treatment regimens. This has limited the therapeutic options for metastatic breast cancer disease requiring exploration of diverse therapeutic models to target tumor specific biomarkers. Methods Differentially expressed breast cancer genes identified through extensive data mapping were studied for their interaction with other target proteins involved in breast cancer progression. The molecular mechanisms by which these signature genes are involved in breast cancer metastasis were also studied through pathway analysis. The potential drug targets for these genes were also identified. Results From 50 DEGs, 20 genes were identified based on fold change and p-value and the data curation of these genes helped in shortlisting 8 potential gene signatures that can be used as potential candidates for breast cancer. Their network and pathway analysis clarified the role of these genes in breast cancer and their interaction with other signaling pathways involved in the progression of disease metastasis. The miRNA targets identified through miRDB predictor provided potential miRNA targets for these genes that can be involved in breast cancer progression. Several FDA approved drug targets were identified for the signature genes easing the therapeutic options for breast cancer treatment. Conclusion The study provides a more clarified role of signature genes, their interaction with other genes as well as signaling pathways. The miRNA prediction and the potential drugs identified will aid in assessing the role of these targets in breast cancer.
- Subjects :
- Microarray datasets
Disease
Computational biology
Biology
Approved drug
Metastasis
03 medical and health sciences
Breast cancer
0302 clinical medicine
microRNA
medicine
skin and connective tissue diseases
lcsh:QH301-705.5
Gene
miRNA
030304 developmental biology
0303 health sciences
Research
Pathway enrichment analysis
General Medicine
medicine.disease
Metastatic breast cancer
lcsh:Biology (General)
Drug development
030220 oncology & carcinogenesis
Gene ontology
Drug-gene network
Subjects
Details
- ISSN :
- 22415793
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Biological Research-Thessaloniki
- Accession number :
- edsair.doi.dedup.....96e41762b2e7d3c42e4b272a071621ef