Intensive Chemotherapy with Cisplatin, Mitoxantrone, Methotrexate and Vincristine in Metastatic Breast Cancer

Eleven patients (pts) with advanced refractory breast carcinoma were treated with combination chemotherapy (Planovin) including mitoxantrone 10 mg/m 2 on day 1, cisplatin 60 mg/m 2 on days 1-2, methotrexate 200 mg/m 2 on day 15, vincristine 2 mg on day 15, leucovorin 15 mg/m 2 on days 15-16 every 3 weeks. Five patients (41%) achieved an objective response with one complete regression. The median duration of response was 4.5 months and the median duration of survival was 8 months. Drug related toxicity consisted mainly of leukopenia (8 pts), nausea and vomiting (6 pts), anemia (7 pts) and thrombocytopenia (4 pts)