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H. pylori clinical isolates have diverse babAB genotype distributions over different topographic sites of stomach with correlation to clinical disease outcomes
- Source :
- BMC Microbiology, BMC Microbiology, Vol 12, Iss 1, p 89 (2012)
- Publication Year :
- 2011
-
Abstract
- Background Intragenomic recombination between babA and babB mediates antigenic variations and may help H. pylori colonization. This study determined whether variable genotypes of babA and babB correlate to different clinical disease outcomes, and can distribute over the different gastric niches. Results This study enrolled 92 clinical strains (45 from peptic ulcer, 27 from gastritis, and 20 from gastric cancer) to detect whether the babA and babB are at locus A or B by PCR reactions using the primers designed from the upstream and variable region of the babA and babB genes. Four genotypes of babA and babB (A B, AB B, A AB, AB AB) were found. The distribution of the 4 genotypes in 92 clinical strains was significantly different among patients with different gastric diseases (p vs. 9.7%, p p p > 0.05). Besides, the study enrolled 19 patients to verify whether variable genotypes of babAB existed in the different gastric niches. Among the patients infected with more than one babAB genotypes over antrum and corpus, there were higher rate of genotypes as A B or AB AB in isolates from antrum than in those from corpus (75.0 % vs. 16.7%, p Conclusions The H. pylori isolate with the AB AB genotype correlates with an increased gastric cancer risk, and colonize in an antrum predominant manner.
- Subjects :
- Microbiology (medical)
DNA, Bacterial
Peptic Ulcer
Genotype
lcsh:QR1-502
Microbiology
lcsh:Microbiology
Bacterial genetics
Helicobacter Infections
Stomach Neoplasms
medicine
Humans
Colonization
Adhesins, Bacterial
biology
Helicobacter pylori
Stomach
Intestinal metaplasia
Sequence Analysis, DNA
medicine.disease
biology.organism_classification
digestive system diseases
medicine.anatomical_structure
Parasitology
Amino Acid Substitution
Gastritis
Immunology
medicine.symptom
Bacterial Outer Membrane Proteins
Research Article
Subjects
Details
- ISSN :
- 14712180
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- BMC microbiology
- Accession number :
- edsair.doi.dedup.....969f0a5427dd6d77bfb63e3d46b937b3