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The discovery of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex and the molecular regulation of synaptic vesicle transmitter release: the 2010 Kavli Prize in neuroscience
- Source :
- Neuroscience. 190:12-20
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Brain function depends on a crucial feature: The ability of individual neurons to share packets of information, known as quantal transmission. Given the sheer number of tasks the brain has to deal with, this information sharing must be extremely rapid. Synapses are specialized points of contact between neurons, where fast transmission takes place. Though the basic elements and functions of the synapse had been established since the 1950s, the molecular basis for regulation of fast synaptic transmitter release was not known 20 years ago. However, around 1990, crucial discoveries were made by Richard Scheller, James Rothman, and Thomas Sudhof, leading a few years later to the formulation of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) hypothesis and a new understanding of the molecular events controlling vesicular release of transmitter in synapses. The 2010 Kavli Prize in neuroscience was awarded to these three researchers, “for their work to reveal the precise molecular basis of the transfer of signals between nerve cells in the brain.”
- Subjects :
- Receptor complex
Neuroscience(all)
Synaptic transmitter
Awards and Prizes
Biology
Synaptic Transmission
Synaptic vesicle
VAMP/synaptobrevin
Synapse
Neurobiology
synapse
Humans
Attachment protein
Brain function
Neurons
Norway
General Neuroscience
Brain
History, 20th Century
United States
Cell biology
synaptotagmin
SNARE
Synapses
Nerve cells
SNAP-25
Synaptic Vesicles
SNARE Proteins
Neuroscience
syntaxin
Subjects
Details
- ISSN :
- 03064522
- Volume :
- 190
- Database :
- OpenAIRE
- Journal :
- Neuroscience
- Accession number :
- edsair.doi.dedup.....968d259fb62f417c72eca5c402f2ee75