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Osteoarthritis year in review 2015: clinical
- Source :
- Osteoarthritis and Cartilage. 24:36-48
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- SummaryThe purpose of this review is to highlight clinical research in osteoarthritis (OA). A literature search was conducted using PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) with the search terms “osteoarthritis [All Fields] AND treatment [All Fields]” and the following limits activated: humans, English language, all adult 19+ years, published between April 1, 2014 and April 1, 2015. A second literature search was then conducted with the search terms “osteoarthritis [All Fields] AND epidemiology [All Fields]”, with the same limits. Reports of surgical outcome, case series, surgical technique, tissue sample or culture studies, trial protocols, and pilot studies were excluded. Of 1523, 150 were considered relevant. Among epidemiologic and observational clinical studies, themes included physical activity, early knee OA, and confidence/instability/falls. Symptom outcomes of pharmacologic treatments were reported for methotrexate, adalimumab, anti-nerve growth factor monoclonal antibodies, strontium ranelate, bisphosphonates, glucosamine, and chondroitin sulfate, and structural outcomes of pharmacologic treatments for strontium ranelate, recombinant human fibroblast growth factor 18, and glucosamine and chondroitin sulfate. Symptom outcomes of non-pharmacologic interventions were reported for: neuromuscular exercise, quadriceps strengthening, weight reduction and maintenance, TENS, therapeutic ultrasound, stepped care strategies, cognitive behavior therapy for sleep disturbance, acupuncture, gait modification, booster physical therapy, a web-based therapeutic exercise resource center for knee OA; hip physical therapy for hip OA; and joint protection and hand exercises for hand OA. Structure outcomes of non-pharmacologic interventions were reported for patellofemoral bracing.
- Subjects :
- medicine.medical_specialty
Epidemiology
Ultrasonic Therapy
Biomedical Engineering
Pain
Thiophenes
Osteoarthritis
Article
Imaging
03 medical and health sciences
0302 clinical medicine
Rheumatology
Strontium ranelate
Acupuncture
Adalimumab
Humans
Medicine
Orthopedics and Sports Medicine
030212 general & internal medicine
Arthroplasty, Replacement
Function
Physical Therapy Modalities
030203 arthritis & rheumatology
Glucosamine
Sleep disorder
Bone Density Conservation Agents
Cognitive Behavioral Therapy
Diphosphonates
business.industry
Chondroitin Sulfates
Resistance Training
medicine.disease
Exercise Therapy
3. Good health
Treatment
Methotrexate
Treatment Outcome
Clinical research
Antirheumatic Agents
Transcutaneous Electric Nerve Stimulation
Physical therapy
Observational study
business
medicine.drug
Subjects
Details
- ISSN :
- 10634584
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Osteoarthritis and Cartilage
- Accession number :
- edsair.doi.dedup.....967c69ecfbb088e3d813f9043248047a