Analysis of colorectal cancer morphology in relation to sex, age, location, and family history

Studies of colorectal cancer (CRC) have suggested different mechanisms of carcinogenesis in men and women, young and old patients, right- and left sided tumors, and sporadic and familial tumors. These differences might be reflected in morphology. CRCs from 1613 patients operated on in 2004–2006 in Sweden were histologically reviewed. Morphology was examined in relation to sex, age groups, location, and family history. Tumors in the right colon were larger, of higher stage, more often poorly differentiated, more mucin-producing, more often had a peritumoral lymphocytic infiltrate and a high level of tumor-infiltrating lymphocytes (TILs), and more seldom had an infiltrating margin than tumors in the left colon and rectum (p