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Loss of MD1 exacerbates myocardial ischemia/reperfusion injury and susceptibility to ventricular arrhythmia
- Source :
- European journal of pharmacology. 844
- Publication Year :
- 2018
-
Abstract
- Myeloid differentiation protein 1(MD1), also known as lymphocyte antigen 86 (LY86), plays an important role in the toll-like receptor 4 (TLR4) signaling pathway. Recent studies show that MD1 is involved in regulating pressure overload-induced cardiac structural and electrical remodeling. However, the effect of MD1 on myocardial ischemia-reperfusion (I/R) injury and I/R related arrhythmia remains unknown. To further investigate that, the present study used MD1-knockout (MD1-KO) mice to study the role of MD1 in regulating myocardial I/R injury and its electrophysiology. The results demonstrate that the loss of MD1 led to a larger infarct size, increased activity of cardiac injury markers, aggravated histological damage, worsened cardiac function and decreased survival rate after myocardial I/R. Meanwhile, MD1 deficiency also aggravated inflammatory responses, promoted cardiomyocyte apoptosis and increased susceptibility to ventricular arrhythmia in mice subjected to myocardial I/R. Furthermore, loss of MD1 enhanced the activation of toll-like receptor 4 (TLR4) / nuclear factor kappa B (NF-κB) signaling pathway after myocardial I/R. Therefore, loss of MD1 exacerbated myocardial I/R injury and increased the susceptibility to ventricular arrhythmia, both of which are possibly related to the up-regulation of TLR4/NF-κB signaling pathway.
- Subjects :
- 0301 basic medicine
Cardiac function curve
Male
medicine.medical_specialty
Myeloid
Inflammation
Myocardial Reperfusion Injury
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Animals
Receptor
Survival rate
Pharmacology
Mice, Knockout
Membrane Glycoproteins
business.industry
Myocardium
NF-kappa B
Arrhythmias, Cardiac
Heart
medicine.disease
Toll-Like Receptor 4
030104 developmental biology
medicine.anatomical_structure
Antigens, Surface
TLR4
Cardiology
medicine.symptom
Signal transduction
business
Reperfusion injury
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18790712
- Volume :
- 844
- Database :
- OpenAIRE
- Journal :
- European journal of pharmacology
- Accession number :
- edsair.doi.dedup.....966f4dfa216d7fe4d5f8e91af6fcc969