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DNA binding of methyl iodide in male and female F344 rats
- Source :
- Carcinogenesis. 12:463-467
- Publication Year :
- 1991
- Publisher :
- Oxford University Press (OUP), 1991.
-
Abstract
- The genotoxic potency of methyl iodide was investigated in a DNA binding study. Male and female F344 rats were exposed to 14C-labelled methyl iodide orally or by inhalation in a closed exposure system. DNA adducts were detected in the liver, lung, stomach and forestomach of the exposed animals. [14C]3-Methyladenine, [14C]7-methylguanine and [14C]O6-methylguanine could be identified by a combination of three different methods of hydrolysing DNA and subsequent HPLC or GC/MS analysis. The highest values of methylated guanines were determined in the stomach and forestomach of the animals following both oral and inhalative exposure. These results demonstrate a systemic genotoxic effect of methyl iodide.
- Subjects :
- Male
Cancer Research
Guanine
Administration, Oral
Mutagen
Biology
medicine.disease_cause
chemistry.chemical_compound
Oral administration
Administration, Inhalation
medicine
Animals
Potency
Carbon Radioisotopes
Hydrocarbons, Iodinated
Lung
Chromatography, High Pressure Liquid
Carcinogen
Adenine
Hydrolysis
Stomach
DNA
General Medicine
Molecular biology
Rats, Inbred F344
Rats
stomatognathic diseases
medicine.anatomical_structure
Liver
chemistry
Biochemistry
Gastric Mucosa
Purines
Toxicity
Female
Methyl iodide
Subjects
Details
- ISSN :
- 14602180 and 01433334
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Carcinogenesis
- Accession number :
- edsair.doi.dedup.....966e36c2962439913031d5f3f455f3a6