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Antigens of the major histocompatibility system in ischemic heart disease and idiopathic dilated cardiomyopathy
- Source :
- Clinical Cardiology. 22:292-296
- Publication Year :
- 1999
- Publisher :
- Wiley, 1999.
-
Abstract
- Background: Although dilated cardiomyopathy (DCM) is a disease of unknown and probably multifactorial etiology, a change in immune mechanisms is presumably significant, with many abnormalities in humoral and cellular responses having been reported. The heart thus becomes the target organ for an initial episode of myocardial damage that triggers an autoimmune response. Hypothesis: The purpose of this study was to analyze the frequency of different human leukocyte antigens in patients with a diagnosis of well-advanced DCM and ischemic heart failure, comparing them with a control group of presumably healthy subjects. Methods: The group with dilated cardiomyopathy consisted of 50 patients (7 women and 43 men), aged from 14 to 64 years. The group with ischemic heart disease included 76 patients (4 women and 72 men), with ages ranging from 34 to 64. The control group, consisting of 1,337 presumably healthy subjects from the Spanish Mediterranean area, was recruited based on paternity studies. Results: Compared with the control group, we found in DCM a greater incidence of B15 (20 vs. 6%) and DQ 3 (83 vs. 50%) antigens. In ischemic heart disease we found a lower incidence of A1 (3 vs. 22%), B8 (5 vs. 12%), and DQ2 (16 vs. 50%) in comparison with the control group. Conclusions: In the Spanish Mediterranean area, the presence of antigens B-15 and DQ3 would be associated with advanced DCM. The absence of antigens A1, B8, and DQ2 would be associated with the occurrence of severe ischemic heart disease.
- Subjects :
- Adult
Cardiomyopathy, Dilated
Male
medicine.medical_specialty
Adolescent
Heart disease
Myocardial Ischemia
Disease
Human leukocyte antigen
Sensitivity and Specificity
HLA Antigens
HLA-DQ Antigens
Internal medicine
Idiopathic dilated cardiomyopathy
Humans
Medicine
Risk factor
Chi-Square Distribution
HLA-A Antigens
business.industry
Dilated cardiomyopathy
Articles
HLA-DR Antigens
General Medicine
Middle Aged
medicine.disease
HLA-B Antigens
Heart failure
Etiology
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 19328737 and 01609289
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Clinical Cardiology
- Accession number :
- edsair.doi.dedup.....965ba6d7ac935a5f3e90b15834f3c4c2