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Small Cell Neuroendocrine Carcinoma With Skeletal Muscle Differentiation
- Source :
- The American Journal of Surgical Pathology. 24:223-230
- Publication Year :
- 2000
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2000.
-
Abstract
- Three cases of neuroendocrine carcinoma showing skeletal muscle differentiation are presented. The tumors were located in the skin and subcutaneous tissue, the urinary bladder, and the nasal cavity respectively, and were composed by two cell types admixed intimately with each other. One cell type had features identical to those seen in conventional small cell neuroendocrine carcinoma, including scanty cytoplasm, round nuclei with fine granular chromatin, immunohistochemical reactivity for neuron-specific enolase, chromogranin and cytokeratins, and electron-dense granules on ultrastructural examination. The second cell type was either plasmacytoid or elongated and straplike, with abundant eosinophilic cytoplasm and irregular nuclei with prominent nucleoli. These cells showed immunohistochemical positivity for desmin, sarcomeric actin, myoglobin, and myogenin. They also exhibited ultrastructural evidence of rhabdomyoblastic differentiation in the form of contractile filaments with abortive Z-band formation. An origin from a cell capable of dual differentiation toward neuroendocrine and rhabdomyoblastic elements is postulated for these tumors.
- Subjects :
- Male
Cell type
Pathology
medicine.medical_specialty
Skin Neoplasms
Cellular differentiation
Nose Neoplasms
Cell
Biology
Cytoplasmic Granules
Small-cell carcinoma
Pathology and Forensic Medicine
Immunoenzyme Techniques
Fatal Outcome
Rhabdomyosarcoma
Biomarkers, Tumor
Chromogranins
medicine
Humans
Muscle, Skeletal
Actin
Aged
Chromogranin A
medicine.disease
Carcinoma, Neuroendocrine
medicine.anatomical_structure
Urinary Bladder Neoplasms
Cytoplasm
Phosphopyruvate Hydratase
biology.protein
Keratins
Female
Surgery
Desmin
Anatomy
Subjects
Details
- ISSN :
- 01475185
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- The American Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....965abb189030654e84856a7480cb458e