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Estradiol and ERβ agonists enhance recognition memory, and DPN, an ERβ agonist, alters brain monoamines
- Source :
- Neurobiology of Learning and Memory. 94:488-498
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Effects of estradiol benzoate (EB), ERα-selective agonist, propyl pyrazole triol (PPT) and ERβ-selective agonists, diarylpropionitrile (DPN) and Compound 19 (C-19) on memory were investigated in OVX rats using object recognition (OR) and placement (OP) memory tasks. Treatments were acute (behavior 4 h later) or sub chronic (daily injections for 2 days with behavior 48 h later). Objects were explored in sample trials (T1), and discrimination between sample (old) and new object/location in recognition trials (T2) was examined after 2–4 h inter-trial delays. Subjects treated sub chronically with EB, DPN, and C-19, but not PPT, discriminated between old and new objects and objects in old and new locations, suggesting that, at these doses and duration of treatments, estrogenic interactions with ERβ contribute to enhancements in recognition memory. Acute injections of DPN, but not PPT, immediately after T1, also enhanced discrimination for both tasks (C19 was not investigated). Effects of EB, DPN and PPT on anxiety and locomotion, measured on elevated plus maze and open field, did not appear to account for the mnemonic enhancements. Monoamines and metabolites were measured following DPN treatment in subjects that did not receive behavioral testing. DPN was associated with alterations in monoamines in several brain areas: indexed by the metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), or the MHPG/norepinephrine (NE) ratio, NE activity was increased by 60–130% in the prefrontal cortex (PFC) and ventral hippocampus, and NE activity was decreased by 40–80% in the v. diagonal bands and CA1. Levels of the dopamine (DA) metabolite, homovanillic acid (HVA), increased 100% in the PFC and decreased by 50% in the dentate gyrus following DPN treatment. The metabolite of serotonin, 5-hydroxyindole acetic acid (5-HIAA), was increased in the PFC and CA3, by approximately 20%. No monoaminergic changes were noted in striatum or medial septum. Results suggest that ERβ mediates sub chronic and acute effects of estrogens on recognition memory and that memory enhancements by DPN may occur, in part, through alterations in monoaminergic containing systems primarily in PFC and hippocampus.
- Subjects :
- Agonist
medicine.medical_specialty
medicine.drug_class
Ovariectomy
Cognitive Neuroscience
Diarylpropionitrile
Prefrontal Cortex
Spatial Behavior
Hippocampus
Experimental and Cognitive Psychology
Statistics, Nonparametric
Article
Open field
Developmental psychology
Discrimination Learning
Rats, Sprague-Dawley
Behavioral Neuroscience
chemistry.chemical_compound
Phenols
Internal medicine
Nitriles
medicine
Animals
Estrogen Receptor beta
Biogenic Monoamines
Maze Learning
Estradiol
Dentate gyrus
Homovanillic acid
Brain
Estrogens
Recognition, Psychology
Rats
Neostriatum
Memory, Short-Term
Endocrinology
Monoamine neurotransmitter
chemistry
Exploratory Behavior
Estradiol benzoate
Pyrazoles
Female
Propionates
Neuroscience
Subjects
Details
- ISSN :
- 10747427
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Learning and Memory
- Accession number :
- edsair.doi.dedup.....9657dcd7e919a764b3734a96a9423fd4