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Defining the proteome of human iris, ciliary body, retinal pigment epithelium, and choroid
- Source :
- Proteomics, vol 16, iss 7
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- The iris is a fine structure that controls the amount of light that enters the eye. The ciliary body controls the shape of the lens and produces aqueous humor. The retinal pigment epithelium and choroid (RPE/choroid) are essential in supporting the retina and absorbing light energy that enters the eye. Proteins were extracted from iris, ciliary body, and RPE/choroid tissues of eyes from five individuals and fractionated using SDS-PAGE. After in-gel digestion, peptides were analyzed using LC-MS/MS on an Orbitrap Elite mass spectrometer. In iris, ciliary body, and RPE/choroid, we identified 2,959, 2,867, and 2,755 non-redundant proteins with peptide and protein false positive rates of
- Subjects :
- Electrophoresis
Proteomics
Male
0301 basic medicine
Biochemistry & Molecular Biology
Proteome
Iris
Ciliary body
Retinal Pigment Epithelium
Biology
Eye
Medical and Health Sciences
Biochemistry
Article
03 medical and health sciences
Information and Computing Sciences
medicine
Humans
Eye Proteins
Iris (anatomy)
Uvea
Eye Disease and Disorders of Vision
Molecular Biology
Aged
Gel
Retina
Retinal pigment epithelium
030102 biochemistry & molecular biology
Choroid
Neurosciences
Middle Aged
Biological Sciences
eye diseases
Cell biology
Biomedicine
030104 developmental biology
medicine.anatomical_structure
Lens (anatomy)
Two-Dimensional
Female
sense organs
Subjects
Details
- ISSN :
- 16159853
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PROTEOMICS
- Accession number :
- edsair.doi.dedup.....9655ae6ef6b149417acbf23a38975e23