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Absence of Neuroinvasive Disease in a Liver Transplant Recipient Who Acquired West Nile Virus (WNV) Infection from the Organ Donor and Who Received WNV Antibodies Prophylactically

Authors :
Anna Pierro
Giorgio Ercolani
Maria Paola Landini
Stefano Menzo
Pasquale Paolo Pagliaro
Maria Cristina Morelli
Maria Rosaria Capobianchi
Giada Rossini
Antonio Daniele Pinna
Florio Ghinelli
Tiziana Lazzarotto
Antonino Di Caro
Paolo Gaibani
Matteo Cescon
Vittorio Sambri
Francesca Cavrini
Gian Luca Grazi
Morelli M.C.
Sambri V.
Grazi G.L.
Gaibani P.
Pierro A.
Cescon M.
Ercolani G.
Cavrini F.
Rossini G.
Capobianchi M.R.
Di Caro A.
Menzo S.
Pagliaro P.P.
Ghinelli F.
Lazzarotto T.
Landini M.P.
Pinna A.D.
Source :
Clinical Infectious Diseases. 51:e34-e37
Publication Year :
2010
Publisher :
Oxford University Press (OUP), 2010.

Abstract

We describe the first case of West Nile virus (WNV) infection in Europe with transmission from donor to recipient following liver transplantation. The infection was detected in the recipient 3 days after transplantation, during the asymptomatic phase. We also report an innovative prophylactic strategy based on infusion of WNV hyperimmune plasma and gamma globulins that could be effective in preventing the appearance of a neuroinvasive disease.

Details

ISSN :
15376591 and 10584838
Volume :
51
Database :
OpenAIRE
Journal :
Clinical Infectious Diseases
Accession number :
edsair.doi.dedup.....963826fcc5b9c97f66c4ba2d8072e467
Full Text :
https://doi.org/10.1086/655146