Back to Search
Start Over
Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery
- Source :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
-
Abstract
- Hollow titanium dioxide (TiO2) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO2 nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance and drug delivery. We generate magnetic TiO2 nanotubes (TiO2NTs) by incorporating a ferrofluid containing Ø ≈ 10 nm iron oxide nanoparticles in planar sheets of weakly connected TiO2 nanotubes. After thermal annealing, the magnetic tubular arrays are loaded with therapeutic drugs and then sonicated to separate the nanotubes. We demonstrate that magnetic TiO2NTs are non-toxic for HeLa cells at therapeutic concentrations (≤200 µg/mL). Adhesion and endocytosis of magnetic nanotubes to a layer of HeLa cells are increased in the presence of a magnetic gradient field. As a proof-of-concept, we load the nanotubes with the topoisomerase inhibitor camptothecin and achieve a 90% killing efficiency. We also load the nanotubes with oligonucleotides for cell transfection and achieve 100% cellular uptake efficiency. Our results demonstrate the potential of magnetic TiO2NTs for a wide range of biomedical applications, including site-specific delivery of therapeutic drugs.
- Subjects :
- Ferrofluid
Materials science
Sonication
lcsh:Medicine
Metal Nanoparticles
02 engineering and technology
010402 general chemistry
01 natural sciences
Ferric Compounds
Proof of Concept Study
Article
chemistry.chemical_compound
Drug Delivery Systems
Magnetic properties and materials
medicine
Humans
lcsh:Science
Titanium
Drug Carriers
Multidisciplinary
Nanotubes
Photoelectron Spectroscopy
lcsh:R
Synthesis and processing
technology, industry, and agriculture
Adhesion
021001 nanoscience & nanotechnology
equipment and supplies
0104 chemical sciences
Drug Liberation
Magnetic Fields
chemistry
Chemical engineering
Titanium dioxide
Drug delivery
lcsh:Q
Camptothecin
Nanocarriers
Topoisomerase I Inhibitors
0210 nano-technology
human activities
Iron oxide nanoparticles
Fluorescein-5-isothiocyanate
medicine.drug
HeLa Cells
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....9630f0ea41f6d985881df2cb695ae696