Human rotavirus vaccine (RIX4414) efficacy in the first two years of life

Rotaviruses (RV) are a major cause of severe gastroenteritis (GE) in children aged 10%. The number of unsolicited symptoms and SAEs reported was similar between both groups. Thirteen deaths (RIX4414 = 6; placebo = 7) occurred during the study. All SAEs and deaths in the RIX4414 group were considered unrelated to vaccination. Two oral doses of RIX4414 vaccine provided a substantial level of protection against severe RVGE in Chinese children during the first two years of life.