Back to Search
Start Over
Staphylococcus aureus Skin and Soft Tissue Infection Recurrence Rates in Outpatients: A Retrospective Database Study at 3 US Medical Centers
- Source :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
- Publication Year :
- 2020
- Publisher :
- Oxford University Press, 2020.
-
Abstract
- Background Staphylococcusaureus skin and soft tissue infections (SA-SSTIs) are common in healthcare and community settings, and recurrences occur at variable frequency, even after successful initial treatment. Knowing the exact burden and timing of recurrent disease is critical to planning and evaluating interventions to prevent recurrent SSTIs. Methods In this retrospective study, SSTI cases in patients aged ≥18 years at 3 US medical centers (Columbia, Chicago, Vanderbilt) between 2006 and 2016 were analyzed according to a biennial cohort design. Index SSTIs (with or without key comorbidities), either microbiologically confirmed to be SA-SSTI or not microbiologically tested (NMT-SSTI), were recorded within 1 calendar year and followed up for 12 months for recurrent infections. The number of index cases, proportion of index cases with ≥1 recurrence(s), time to first recurrence, and number of recurrences were collected for both SA-SSTI and NMT-SSTI events. Results In the most recent cohorts, 4755 SSTI cases were reported at Columbia, 2873 at Chicago, and 6433 at Vanderbilt. Of these, 452, 153, and 354 cases were confirmed to be due to S. aureus. Most cases were reported in patients without key comorbidities. Across centers, 16.4%–19.0% (SA-SSTI) and 11.0%–19.2% (NMT-SSTI) of index cases had ≥1 recurrence(s). In patients without key comorbidities, more than 60% of index SSTIs with recurrences had only 1 recurrence, half of which occurred in the first 3 months following primary infection. Conclusions SA-SSTI recurrences are common among healthy adults and occur in at least 1 in 6 individuals during the 1 year following the primary event.<br />The number of Staphylococcus aureus skin and soft tissue infections patients recorded at 3 US medical centers during 2006–2016 was stable and lacked key comorbidities. Most patients with recurrences had 1 recurrence, half of which occurred in the first 3 months following primary infection.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Adult
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty
Staphylococcus aureus
Adolescent
030106 microbiology
SSTI recurrence
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Antibiotic resistance
Recurrence
Internal medicine
Outpatients
medicine
Humans
skin and soft tissue infection (SSTI)
030212 general & internal medicine
antimicrobial resistance
Online Only Articles
Retrospective Studies
business.industry
Soft Tissue Infections
Soft tissue
Retrospective cohort study
medicine.disease
Comorbidity
Methicillin-resistant Staphylococcus aureus
Anti-Bacterial Agents
Community-Acquired Infections
Major Articles and Commentaries
Infectious Diseases
AcademicSubjects/MED00290
Soft tissue infection
Staphylococcal Skin Infections
business
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 15376591 and 10584838
- Volume :
- 73
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....962a7a752101dcc2e71083661b3a7298