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Aspirin metabolism and efficacy in postoperative dental pain
- Source :
- British Journal of Clinical Pharmacology. 17:697-701
- Publication Year :
- 1984
- Publisher :
- Wiley, 1984.
-
Abstract
- Aspirin 1200 mg was compared with placebo in a randomised, double-blind, crossover study in 15 patients with postoperative pain after removal of impacted lower third molars. Over a 5 h investigation period, patients reported significantly less pain (P less than 0.01) after treatment with aspirin, than after treatment with placebo. Peak concentrations of aspirin occurred at 15 min after dosage. Significant negative correlations were observed between plasma aspirin esterase activity and both AUC aspirin (r = -0.904, P less than 0.001) and AUC analgesia (r = -0.91, P less than 0.001). Similarly, a significant correlation was observed between AUC aspirin and AUC analgesia (r = 0.96, P less than 0.001). Evidence from this study would suggest that an individual's pain relief in postoperative dental pain is determined by the rate of aspirin hydrolysis to salicylate.
- Subjects :
- Adult
Time Factors
Adolescent
Analgesic
Placebo
Random Allocation
Double-Blind Method
Aspirin esterase activity
medicine
Humans
Pharmacology (medical)
Pharmacology
Clinical Trials as Topic
Pain, Postoperative
Aspirin
business.industry
Tooth, Impacted
Metabolism
Crossover study
Clinical trial
Anesthesia
Tooth Extraction
Female
business
Carboxylic Ester Hydrolases
After treatment
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 03065251
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- British Journal of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....96260b99b79393b2c7f07599cd634196