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Dual Role of miR-122 in Molecular Pathogenesis of Viral Hepatitis
- Source :
- Hepatitis Monthly
- Publication Year :
- 2012
-
Abstract
- The hepatic microRNA (miRNA), miR-122, is the most abundant miRNA within the liver, where it accounts for 70% of the total miRNA pool. It is known that miR-122, as an unusual host factor, increases the abundance of hepatitis C virus (HCV) RNA in HCV infection by binding directly to the 5’-UTR of the viral genome. Therefore, it has been suggested as a potential target for the treatment of hepatitis C. However, recent evidence shows that miR-122 decreases HBV replication through the inhibitory effect of p53 on HBV transcription, and consequently it acts as a tumor-suppressor through both a decrease in HBV replication and by directly targeting cyclin G1, as well as Wnt/beta-catenin, and NDRG3 pathways. This paper will briefly discuss the underlying mechanisms for the dual role of miR-122 in viral hepatitis, and explains why therapeutic applications of miR-122 may differ based on the underlying disease.
- Subjects :
- Micro RNAs
Hepatology
business.industry
Cyclin G1
Hepatitis C virus
Hepatitis C
medicine.disease
medicine.disease_cause
Virology
Hepatitis B virus PRE beta
Infectious Diseases
Editorial
Transcription (biology)
microRNA
medicine
MiR-122
Hepatocyte Nuclear Factors
business
Viral hepatitis
Host factor
Subjects
Details
- ISSN :
- 17353408
- Volume :
- 12
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Hepatitis monthly
- Accession number :
- edsair.doi.dedup.....961d4aa78576823f2cf2f05efd810138